Task- and resting-state functional connectivity of brain regions related to affection and susceptible to concurrent cognitive demand.
Task- and resting-state functional connectivity of brain regions related to affection and susceptible to concurrent cognitive demand.
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DOI：
10.1016/j.neuroimage.2013.01.046
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发表时间：
2013-05-15
期刊：
影响因子：
5.7
通讯作者：
Eickhoff SB
中科院分区：
文献类型：
--
作者：
Kellermann TS;Caspers S;Fox PT;Zilles K;Roski C;Laird AR;Turetsky BI;Eickhoff SB
最近的一项功能磁共振成像研究揭示了对刺激进行情感处理的神经反应，无论刺激效价如何，在眶额皮层（OFC）和双侧杏仁核（AMY）中都需要明显的注意：激活随着认知需求的增加而减少。为了进一步表征与这种衰减相关的网络，我们在这里根据这些区域的功能特性和任务相关和任务无关状态下的连接模式来表征这些区域。 BrainMap 数据库激活种子区域 OFC 和双侧 AMY 的所有实验均已确定。使用检索到的实验的行为元数据定量推断它们的功能特征。任务依赖性功能连接的特征是与这些种子区域显着共同激活的元分析连接模型（MACM）。对 100 名健康受试者样本进行的任务无关静息态功能连接分析对这些分析进行了补充。在任务依赖性 MACM 分析中，所有三个种子区域均与膝下扣带回 (SGC)、楔前叶 (PCu) 和伏隔核 (NAcc) 共同激活。与任务无关的静息态连接显示种子仅与 SGC 显着耦合，但与 PCu 和 NAcc 不显着耦合。此外，前一个区域（SGC）被证明与网络中涉及的所有其他区域具有显着的静息态连接，这些区域连接到情绪处理可能受到认知干扰因素调节的区域。根据其功能概况和连接模式，我们建议 SGC 可能作为已识别网络中的关键枢纽，例如链接自传信息 [PCu]、奖励 [NAcc]、（强化）价值观 [OFC] 和情感意义 [AMY]。反过来，这样的作用可能会让 SGC 影响 OFC 和 AMY 来调节情感处理。
A recent fMRI-study revealed neural responses for affective processing of stimuli for which overt attention irrespective of stimulus valence was required in the orbitofrontal cortex (OFC) and bilateral amygdala (AMY): activation decreased with increasing cognitive demand. To further characterize the network putatively related to this attenuation, we here characterized these regions with respect to their functional properties and connectivity patterns in task-dependent and task-independent states. All experiments of the BrainMap database activating the seed regions OFC and bilateral AMY were identified. Their functional characteristics were quantitatively inferred using the behavioral meta-data of the retrieved experiments. Task-dependent functional connectivity was characterized by meta-analytic connectivity modeling (MACM) of significant co-activations with these seed regions. Task-independent resting-state functional connectivity analysis in a sample of 100 healthy subjects complemented these analyses. All three seed regions co-activated with subgenual cingulum (SGC), precuneus (PCu) and nucleus accumbens (NAcc) in the task-dependent MACM analysis. Task-independent resting-state connectivity revealed significant coupling of the seeds only with the SGC, but not the PCu and the NAcc. The former region (SGC) moreover was shown to feature significant resting-state connectivity with all other regions implicated in the network connected to regions where emotional processing may be modulated by a cognitive distractor. Based on its functional profile and connectivity pattern, we suggest that the SGC might serve as a key hub in the identified network, as such linking autobiographic information [PCu], reward [NAcc], (reinforce) values [OFC] and emotional significance [AMY]. Such a role, in turn, may allow the SGC to influence the OFC and AMY to modulate affective processing.