Left ventricular stiffness during diastole and systole: the influence of changes in volume and inotropic state.
Left ventricular stiffness during diastole and systole: the influence of changes in volume and inotropic state.
复制标题
舒张期和收缩期左心室僵硬度：容量和正性肌力状态变化的影响。
DOI：
10.1093/cvr/6.1.95
复制
发表时间：
1972
影响因子：
10.8
通讯作者：
J. H. Mitchell
中科院分区：
文献类型：
--
作者：
G. Templeton;R. Ecker;J. H. Mitchell
一种新的技术已经发展到研究在体左心室在舒张期和收缩期的力学特性。一个流量脉冲发生器被用来诱导正弦体积变化的恒定幅度到一个等容收缩的左心室的频率比心脏的几倍。由此产生的峰间压力变化用于确定体积刚度或弹性，即压力变化与体积变化的比率。体积刚度的测定是可能的，通过减去一个平均的未扰动的压力周期从一个相当的扰动周期期间获得的流量脉冲发生器的使用。研究了心室容积、心率和去甲肾上腺素变化对容积刚度的个体效应。对于这些干预，对于任何给定的犬，建立了体积刚度和心室压力之间的单一线性关系。心室容积和心率的增加以及去甲肾上腺素的给药导致收缩压峰值和容积刚度值较高。舒张期压力和僵硬度的增加是由较大的心室容积和某些较高的心率引起的。
A new technique has been developed to investigate in vivo the mechanical properties of the left ventricle during both diastole and systole. A flow-pulse generator was used to induce sinusoidal volume changes of constant amplitude into an isovolumically contracting left ventricle at a frequency several times greater than that of the heart. The resulting peak-to-peak pressure changes were used to determine volume stiffness or elastance, the ratio of the change in pressure to the change in volume. Determination of volume stiffness was made possible by subtraction of an averaged unperturbed pressure cycle from a comparable perturbed cycle obtained during use of the flow-pulse generator. The individual effects on volume stiffness of changes in ventricular volume, heart rate, and noradrenaline were studied. For these interventions, a single linear relationship between volume stiffness and ventricular pressure was established for any given dog. An increase in ventricular volume and in heart rate and the administration of noradrenaline resulted in higher values of peak systolic pressure and volume stiffness. Diastolic increases in pressure and stiffness were elicited by larger ventricular volumes and by certain higher heart rates.