Evidence for functional relatedness of products encoded by the transforming sequences of human adenovirus types 5 and 12.
Evidence for functional relatedness of products encoded by the transforming sequences of human adenovirus types 5 and 12.
复制标题
人类腺病毒 5 型和 12 型转化序列编码产物功能相关性的证据。
DOI：
10.1016/0042-6822(81)90023-4
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发表时间：
1981
期刊：
影响因子：
3.7
通讯作者：
R. Galos
中科院分区：
文献类型：
--
作者：
J. Williams;Y. Ho;R. Galos
宿主范围和宿主范围缺失突变体的5型腺病毒属于两个互补组，其突变病变地图物理上的左11%的5型基因组，有效地补充混合感染的12型腺病毒。12型对这些早期功能突变体的互补作用与先前发现的其他两组早期功能突变体的互补作用的缺乏相反，并且与由相应血清型的早期区域1编码的产物之间的功能相关性一致。没有发现5型突变体和12型突变体之间重组的证据。
Host-range and host-range deletion mutants of type 5 adenovirus belonging to two complementation groups, whose mutational lesions map physically within the left 11% of the type 5 genome, were efficiently complemented in mixed infection by type 12 adenovirus. The complementation of these early function mutants by type 12 is in contrast to the lack of complementation found previously for two other groups of early function mutants, and it is consistent with functional relatedness between products encoded by early region 1 of the respective serotypes. No evidence for recombination between the type 5 mutants and type 12 was found.