Efficient Development of Luminescent Lanthanide(III) Complexes by Solid-Phase Synthesis and On-Resin Screening
Efficient Development of Luminescent Lanthanide(III) Complexes by Solid-Phase Synthesis and On-Resin Screening
复制标题
通过固相合成和树脂筛选高效开发发光镧系元素 (III) 配合物
DOI：
10.1002/asia.201300759
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kazuya Kikuchi
中科院分区：
文献类型：
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作者：
Tatsuya Nakamura;Shin Mizukami;Miho Tanaka;Kazuya Kikuchi
发光镧系元素配合物的时间分辨发光测量由于其高灵敏度而在生物测定和高通量筛选中具有优势。尽管近年来在能量传递机制和基于分子轨道的计算分子设计方面取得了很大进展，但新的发光镧系配合物的量子产率仍然很难估计。本文中，通过酰胺缩合和Pd催化的偶联反应制备了发光镧系元素配合物的固相库，并用酶标仪筛选了它们的发光性质。在固相库的时间分辨发光强度与通过使用液相化学合成的相应复合物的时间分辨发光强度之间观察到良好的相关性。这种方法使快速和有效的开发新的敏化剂的Sm III，Eu III，和Tb III发光。因此，固相组合合成与树脂上筛选相结合导致发现了各种各样的发光敏化剂。
Time‐resolved luminescence measurements of luminescent lanthanide complexes have advantages in biological assays and high‐throughput screening, owing to their high sensitivity. In spite of the recent advances in their energy‐transfer mechanism and molecular‐orbital‐based computational molecular design, it is still difficult to estimate the quantum yields of new luminescent lanthanide complexes. Herein, solid‐phase libraries of luminescent lanthanide complexes were prepared through amide‐condensation and Pd‐catalyzed coupling reactions and their luminescent properties were screened with a microplate reader. Good correlation was observed between the time‐resolved luminescence intensities of the solid‐phase libraries and those of the corresponding complexes that were synthesized by using liquid‐phase chemistry. This method enabled the rapid and efficient development of new sensitizers for SmIII, EuIII, and TbIIIluminescence. Thus, solid‐phase combinatorial synthesis combined with on‐resin screening led to the discovery of a wide variety of luminescent sensitizers.