Chemical biology approaches to uncovering nuclear ROS control.
Chemical biology approaches to uncovering nuclear ROS control.
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DOI：
10.1016/j.cbpa.2023.102352
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发表时间：
2023-06
影响因子：
7.8
通讯作者：
Junbing Zhang;L. Bar-Peled
中科院分区：
文献类型：
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作者：
Junbing Zhang;L. Bar-Peled
包括活性氧（ROS）在内的活性代谢物浓度升高，会损害所有大分子，导致细胞保真度受损。在这方面，细胞核中ROS的控制对于细胞内稳态是必不可少的，并且细胞核ROS的失调已归因于多种病理和某些化疗的作用机制。核活性氧是如何产生、解毒和感知的，人们对此知之甚少，部分原因是历史上缺乏精确产生和检测活性氧的工具。在这里，我们总结了化学生物学的最新进展，这些方法已经被开发用于研究核ROS，并强调了这些工具如何在理解其调控方面取得重大突破。化学生物学方法的持续发展和应用，以了解核活性氧有望解开人类生理学和疾病的基本见解。
Heightened concentrations of reactive metabolites, including reactive oxygen species (ROS), can damage all macromolecules leading to the erosion of cellular fidelity. In this regard, the control of ROS in the nuclues is essential for cellular homeostasis, and dysregulation of nuclear ROS has been attributed to multiple pathologies and the mechanism of action of certain chemotherapies. How nuclear ROS is generated, detoxified and sensed is poorly understood, and stems in part, from a historical lack of tools that allow for its precise generation and detection. Here, we summarize the latest advances in chemical biology inspired approaches that have been developed to study nuclear ROS and highlight how these tools have led to major breakthroughs in understanding its regulation. The continued development and application of chemical biology approaches to understand nuclear ROS promises to unlock fundamental insights into human physiology and disease.