Psoriasis, Vitiligo, and Biologic Therapy: Case Report and Narrative Review.
Psoriasis, Vitiligo, and Biologic Therapy: Case Report and Narrative Review.
复制标题
DOI：
10.1159/000514198
复制
发表时间：
2021-05
影响因子：
0.9
通讯作者：
Parodi A
中科院分区：
文献类型：
--
作者：
Burlando M;Muracchioli A;Cozzani E;Parodi A
银屑病和白癜风是两种多因素免疫介导的疾病，部分共同的致病基础。它们在同一患者中共存，尽管不常见，但在文献中已有记载。此外，还报道了几例由生物药物引起的银屑病患者的白癜风。然而，在引入生物疗法后，银屑病和先前存在的白癜风的改善也被描述。到目前为止，抗肿瘤坏死因子-α是被引用最多的一组生物药物，可以在银屑病患者中诱导新发白癜风或原有白癜风的进展。即使是抗IL-12/23类似乎也会诱发白癜风(就像我们的病例一样)，甚至更糟。抗IL-17药物可导致原有白癜风的进展，但迄今为止，尚无文献报道有抗IL-23类药物的病例。
Psoriasis and vitiligo are 2 multifactorial immune-mediated diseases, partially sharing pathogenetic underpinnings. Their coexistence in the same patient, although uncommon, is documented in the literature. Further, several cases of vitiligo induced by biological drugs in psoriatic patients are reported. However, improvements in psoriasis and pre-existing vitiligo after the introduction of biological therapy are also described. To date, anti-TNF-alpha is the most cited group of biological drugs that induce new-onset vitiligo or progression of pre-existence vitiligo in psoriatic patients. Even anti-IL-12/23 class would seem to induce vitiligo (as in our case) or even worse it. Anti-IL-17 drugs induce a progression of pre-existing vitiligo while, to date, no cases are reported in literature considering anti-IL-23 class.