Cellulose acetate hollow fiber membranes blended with phospholipid polymer and their performance for hemopurification
Cellulose acetate hollow fiber membranes blended with phospholipid polymer and their performance for hemopurification
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DOI：
10.1163/1568562041526450
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发表时间：
2004-01
期刊：
影响因子：
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通讯作者：
Sang‐Ho Ye;J. Watanabe;K. Ishihara
中科院分区：
文献类型：
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作者：
Sang‐Ho Ye;J. Watanabe;K. Ishihara
由合成聚合物制成的市售中空纤维膜（HFM），包括用作血液纯化膜的醋酸纤维素（CA）HFM，需要通过抑制蛋白质吸附和凝块形成来改善血液相容性。采用干-湿纺工艺制备了2-甲基丙烯酰氧乙基磷酰胆碱（MPC）共聚物（MPC和甲基丙烯酸正丁酯（BMA）组成的PMB 30）与CA HFM共混物。通过表征其结构、渗透性和蛋白质吸附等性能来评价其性能。CA/PMB 30共混HFM的结构变化，如孔隙率增加，大孔的发展和活性层的厚度减少。CA/PMB 30共混HFM的结构和透气性可通过改变制备条件进行调控。此外，CA/PMB 30共混HFM具有良好的渗透性，低蛋白吸附和低污垢性能在渗透实验中相比，CA HFM，因为亲水性和血液相容性的MPC共聚物（PMB 30）存在于HFM的表面。
Commercially available hollow fiber membranes (HFMs) made from synthetic polymers, including cellulose acetate (CA) HFMs, used as hemopurification membranes, need to improve in hemocompatibility, by suppressing protein adsorption and clot formation. In this study, CA HFMs blended with 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer (PMB30 composed of MPC and n-butyl methacrylate (BMA)) were prepared by a dry-jet wet spinning process. Their performances were evaluated by characterizing their properties such as structure, permeability and protein adsorption. CA/PMB30-blend HFMs showed structure changes such as increase of porosity, development of large pores and decreasing of the thickness of the active layer. And the structure and permeability of CA/PMB30-blend HFMs were controllable by changing preparation conditions. Also, the CA/PMB30-blend HFMs had good permeability, low protein adsorption and low fouling property during the permeability experiment in comparison with CA HFMs, because the hydrophilic and hemocompatible MPC copolymer (PMB30) existed on the surface of the HFM.