REPRODUCTIVE PROBLEMS AND BIRTH-DEFECTS IN SURVIVORS OF WILMS TUMOR AND THEIR RELATIVES
REPRODUCTIVE PROBLEMS AND BIRTH-DEFECTS IN SURVIVORS OF WILMS TUMOR AND THEIR RELATIVES
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DOI：
10.1002/mpo.2950160403
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发表时间：
1988-01-01
期刊：
影响因子：
--
通讯作者：
MYERS, MH
中科院分区：
文献类型：
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作者：
BYRNE, J;MULVIHILL, JJ;MYERS, MH
在一项对47名Wilms肿瘤幸存者及其77名同胞对照的回顾性队列研究中，女性幸存者与其同胞对照相比，任何不良活产结局（包括出生缺陷）的风险增加了4倍（风险比为4.1; 95%置信区间为1.7-10.1）。男性幸存者的妻子没有明显的过度风险问题怀孕。这些家庭存在许多严重的生殖问题和重大出生缺陷，例如两名幸存者患有原发性闭经，两名幸存者和一名对照组患有双角子子宫，一名男性幸存者和一名男性对照组患有精神发育迟缓。一名女性幸存者的儿子死于双侧威尔姆斯肿瘤。女性幸存者后代的出生缺陷与宫内限制（可能是由于辐射诱导的纤维化）或与Wilms肿瘤相关的畸形复合体相一致。Wilms '肿瘤的女性幸存者出现各种生殖问题的风险增加，从不育到胎儿丢失，早产和后代出生缺陷。此外，肾母细胞瘤幸存者的亲属可能有相关的出生缺陷的风险，具有临床意义的后果。
In a retrospective cohort study of 47 Wilms'' tumor survivors and their 77 sibling controls, female survivors had a fourfold excess risk (risk ratio, 4.1; 95% confidence interval, 1.7-10.1) for any adverse livebirth outcome, including birth defects, compared with their sibling controls. Wives of male survivors had no apparent excess risk for problem pregnancies. The families had a number of severe reproductive problems and major birth defects, such as primary amenorrhea in two survivors, bicornuate uterus in two survivors and one control, and mental retardation in one male survivor and a male control. The son of a female survivor died after bilateral Wilms'' tumors. Birth defects in the offspring of female survivors are compatible either with intrauterine constraint, possibly due to radiation-induced fibrosis or with the complex of malformations associated with Wilms'' tumor. Female survivors of Wilms'' tumor appear to be at increased risk for a variety of reproductive problems, from sterility to fetal loss, early delivery, and birth defects in offspring. Furthermore, relatives of survivors of Wilms'' tumor may be at risk of having associated birth defects, with clinically significant consequences.