INGESTED ARSENIC AND INTERNAL CANCER - A HISTORICAL COHORT STUDY FOLLOWED FOR 33 YEARS
INGESTED ARSENIC AND INTERNAL CANCER - A HISTORICAL COHORT STUDY FOLLOWED FOR 33 YEARS
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DOI：
10.1093/oxfordjournals.aje.a117421
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发表时间：
1995-02-01
影响因子：
5
通讯作者：
AOYAMA, H
中科院分区：
文献类型：
--
作者：
TSUDA, T;BABAZONO, A;AOYAMA, H
进行了一项历史队列研究，以调查摄入砷的长期影响。1959年名单上的454名居民被跟踪到1992年。他们住在一个砷污染的地区，在日本新泻县的中城町，并使用含有无机砷的井水。据估计，接触期约为5年（1955-1959年）。对1959年至1992年期间死亡的人的死亡证明进行了检查，估计454名居民中共有113人饮用了含有高剂量砷（大于或等于1 ppm）的井水。这113名居民的标化死亡率比为肺癌15.69（观察/预期= 8/0.51; 95%置信区间（CI）7.38-31.02）和尿路癌31.18（观察/预期= 3/0.10; 95% CI 8.62-91.75）。考克斯比例风险分析表明，最高暴露水平组（大于或等于1 ppm）与背景暴露水平组（0.001 ppm）的风险比对于所有死亡为1.74（95% CI 1.10-2.74），对于所有癌症为4.82（95% CI 2.09-11.14）。根据1959年慢性砷中毒的皮肤体征进行的分析表明，它们是随后癌症发展的有用危险指标。在肺癌的发展中，有证据表明砷摄入量和吸烟习惯之间存在协同作用。
A historical cohort study was conducted to investigate the long-term effect of exposure to ingested arsenic. The 454 residents who had been identified in a list made in 1959 were followed until 1992. They lived in an arsenic-polluted area, called Namiki-cho, Nakajo-machi, in Niigata Prefecture, Japan, and used well water containing inorganic arsenic. The exposure period was estimated to be about 5 years (1955-1959). Death certificates for the people who died between 1959 and 1992 were examined, and a total of 113 of the 454 residents were estimated to have drunk well water containing a high dose of arsenic (greater than or equal to 1 ppm). The standardized mortality rate ratios of these 113 residents were 15.69 for lung cancer (observed/expected = 8/0.51; 95% confidence interval (CI) 7.38-31.02) and 31.18 for urinary tract cancer (observed/expected = 3/0.10; 95% CI 8.62-91.75). Cox's proportional hazard analyses demonstrated that the hazard ratios of the highest exposure level group (greater than or equal to 1 ppm) versus the background exposure level group (0.001 ppm) were 1.74 (95% CI 1.10-2.74) for ail deaths and 4.82 (95% CI 2.09-11.14) for all cancers. The analysis according to the skin signs of chronic arsenicism in 1959 showed that they were useful risk indicators for subsequent cancer development. In the development of lung cancer, there was evidence of synergism between arsenic intake and smoking habit.