Varicella zoster virus DNA does not accumulate in infected human neurons
Varicella zoster virus DNA does not accumulate in infected human neurons
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DOI：
10.1016/j.virol.2014.04.014
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发表时间：
2014-06-01
期刊：
影响因子：
3.7
通讯作者：
Gilden, Don
中科院分区：
文献类型：
--
作者：
Baird, Nicholas L.;Bowlin, Jacqueline L.;Gilden, Don
水痘带状疱疹病毒（Varicella zoster virus，VZV）是一种专属于人类的嗜神经性α疱疹病毒。目前尚不清楚为什么在低感染复数下用VZV体外感染的人神经元不表现出细胞病变效应（CPE），即使所有VZV基因被转录，来自所有动力学类别的VZV蛋白被翻译并且产生最小感染性病毒。在这里，我们表明，缺乏VZV诱导的CPE与病毒DNA的低丰度相关。(C)2014爱思唯尔公司All rights reserved.
Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA. (C) 2014 Elsevier Inc. All rights reserved.