Latent class analysis shows strong heritability of the child behavior checklist-juvenile bipolar phenotype
Latent class analysis shows strong heritability of the child behavior checklist-juvenile bipolar phenotype
复制标题
DOI：
10.1016/j.biopsych.2006.02.025
复制
发表时间：
2006-11-01
影响因子：
10.6
通讯作者：
Hudziak, James J.
中科院分区：
文献类型：
--
作者：
Althoff, Robert R.;Rettew, David C.;Hudziak, James J.
背景资料：儿童行为检查表（CBCL）已被用于提供儿童双相情感障碍的定量描述。许多报告指出，临床范围内的儿童同时出现注意力问题（AP）、攻击行为（AGG）和强迫性抑郁（AID）综合征更可能符合儿童BPAD的标准。本研究的目的是确定潜在类别分析（LCA）是否可以识别代表CBCL-青少年双相情感障碍（CBCL-JBD）特征的可识别表型，以及该表型是否表明自杀赞同频率增加。CBCL数据是通过对荷兰双胞胎登记处两个大型双胞胎样本中双胞胎母亲的调查获得的。研究的背景是一般社区双胞胎样本。参与者包括来自荷兰双胞胎登记处的6246名10岁荷兰双胞胎。主要结果指标包括AP、AGG和AID分量表项目的生命周期评估以及班级内自杀项目#18和#91的平均值。结果：7级模型最适合女孩，8级模型最适合男孩。男孩或女孩最常见的班级是没有症状的班级。CBCL-JBD表型是最不常见的-约4-5%的男孩和女孩。这个班是唯一一个在CBCL的自杀项目上有显著升高的班级。性别差异存在于各潜在类别中，女孩在没有CBCL-JBD表型的情况下没有表现出攻击性，并且很少单独表现出注意力问题。这些潜在类的高遗传性的证据被发现与优势比。结论：在一般人群样本中，LCA身份CBCL-JBD表型的潜在类，是与自杀率高，是高度遗传性的，并谈到注意力问题，攻击性行为，和焦虑/抑郁症的儿童之间的共患病。
Background: The Child Behavior Checklist (CBCL) has been used to provide a quantitative description of childhood bipolar disorder WAD), Many have reported that children in the clinical range on the Attention Problems (AP), Aggressive Behavior (AGG), and Anxious-Depressed (AID) syndromes simultaneously are more likely to meet the criteria for childhood BPAD. The purpose of this study was to determine if Latent Class Analysis (LCA) could identify beritable phenotypes representing the CBCL-Juvenile Bipolar (CBCL-JBD) profile and whether this phenotype demonstrates increased frequency of suicidal endorsement.Methods. The CBCL data were received by survey of mothers of twins in two large twin samples, the Netherlands Twin Registry. The setting for the study was the general community twin sample. Participants included 6246 10-year-old Dutch twins from the Netherlands Twin Registry. The main outcome measure consisted of the LCA on the items comprising the AP, AGG, and AID subscales and means from the suicidal items #18 and #91 within classes.Results: A 7 class model fit best for girls and an 8 class fit best for boys. The most common class for boys or girls was one with no symptoms. The CBCL-JBD phenotype was the least common-about 4-5% of the boys and girls. This class was the only one that bad significant elevations on the suicidal items of the CBCL. Gender differences were present across latent classes with girls showing no aggression without the CBCL-JBD phenotype and rarely showing attention problems in isolation. Evidence of high heritability of these latent classes was found with odds ratios.Conclusions: In a general population sample, LCA identities a CBCL-JBD phenotype latent class that is associated with high rates of suicidality, is highly heritable, and speaks to the comorbidity between attention problems, aggressive behavior, and anxious/depression in children.