NEUROPSYCHOLOGICAL AND NEURORADIOLOGICAL CORRELATES IN HUNTINGTONS-DISEASE
NEUROPSYCHOLOGICAL AND NEURORADIOLOGICAL CORRELATES IN HUNTINGTONS-DISEASE
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DOI：
10.1136/jnnp.51.10.1259
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发表时间：
1988-10-01
影响因子：
11
通讯作者：
FOLSTEIN, M
中科院分区：
文献类型：
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作者：
STARKSTEIN, SE;BRANDT, J;FOLSTEIN, M
对34例亨廷顿病患者的CT扫描进行了皮质和皮质下萎缩的测量。双尾核比率（BCR）与眼动量表（r = 0.44，p < 0.01）、日常生活能力量表（r = 0.57，p < 0.001）和简易精神状态检查量表（r = 0.49，p < 0.01）之间存在显著相关性。BCR值与舞蹈病或自主运动障碍的严重程度之间没有相关性。对18名亨廷顿病患者进行的详细神经心理学评估显示，BCR和符号数字模式测试（r = 0.65，p < 0.01）与连线测试的A部分（r = 0.72，p < 0.001）和B部分（r = 0.80，p < 0.0001）之间存在显著相关性。这些数据支持灵长类动物的工作，证明尾状核在认知和眼功能中的作用，但不在运动控制（由putamino-subthalamic系统控制）中。与亨廷顿氏病中尾状核萎缩相关的特定认知技能是在灵长类动物研究中报道的由额尾状核回路系统提供的：眼球运动、概念追踪、集合转移和心理速度。
Measurements of cortical and subcortical atrophy were made on CT scans of 34 patients with Huntington''s disease. Significant correlations were found between the bicaudate ratio (BCR) and an eye movement scale (r = 0.44, p < 0.01), and activities of daily living scale (r = 0.57, p < 0.001) and the Mini-Mental State Exam (r = 0.49, p < 0.01). No correlations were found between BCR values and severity of chorea or voluntary motor impairment. A detailed neuropsychological evaluation of 18 Huntington''s disease patients showed significant correlations between the BCR and Symbol Digit Modalities test (r = 0.65, p < 0.01), and parts A (r = 0.72, p < 0.001) and B (r = 0.80, p < 0.0001) of the Trail Making Test. These data support work in primates that demonstrates the role of the caudate nucleus in cognitive and oculomotor functions, but not in motor control (which is governed by putamino-subthalamic systems). The specific cognitive skills correlated with caudate atrophy in Huntington''s disease are those reported in primate work to be served by the frontal-caudate loop system: eye movements, conceptual tracking, set shifting and psychomotor speed.