Electrophysiology and immunohistochemistry in the hippocampal CA1 and the dentate gyrus of rats chronically exposed to 1-bromopropane, a substitute for specific chlorofluorocarbons
Electrophysiology and immunohistochemistry in the hippocampal CA1 and the dentate gyrus of rats chronically exposed to 1-bromopropane, a substitute for specific chlorofluorocarbons
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DOI：
10.1016/j.neuroscience.2003.12.025
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发表时间：
2004-01-01
期刊：
影响因子：
3.3
通讯作者：
Hori, H
中科院分区：
文献类型：
--
作者：
Fueta, Y;Fukuda, T;Hori, H
1-溴丙烷是一种新引入的特定氯氟烃的替代品，由于臭氧层的破坏而被禁止生产。在这项研究中，我们分析了重复吸入1-溴丙烷在海马CA 1区和齿状回12周诱导的去抑制作用。此外，1-溴丙烷吸入停止后4周检查去抑制作用的逆转。将暴露大鼠置于浓度为700 ppm的不锈钢吸入室中，而对照组仅在相同类型的室中提供室内空气。群体锋电位的成对脉冲抑制显著降低（P
1-Bromopropane is a newly introduced substitute for specific chlorofluorocarbons whose production was prohibited because of depletion of ozone layers. In this study, we analyzed disinhibitory effects induced by repetitive inhalation of 1-bromopropane for 12 weeks in the hippocampal CA1 and the dentate gyrus. In addition, reversal of the disinhibitory effects was examined 4 weeks after 1-bromopropane inhalation ceased. Exposure rats were placed in a stainless steel inhalation chamber at a concentration of 700 ppm, while the control group was provided only room air in the same type of chamber. Paired-pulse inhibition of population spike was considerably decreased (P