VASOPRESSIN ADMINISTRATION VIA MICRODIALYSIS INTO THE SEPTUM INTERFERES WITH THE ACQUISITION OF SPATIAL MEMORY IN RATS
VASOPRESSIN ADMINISTRATION VIA MICRODIALYSIS INTO THE SEPTUM INTERFERES WITH THE ACQUISITION OF SPATIAL MEMORY IN RATS
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DOI：
10.1016/0304-3940(92)90622-e
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发表时间：
1992-08-03
影响因子：
2.5
通讯作者：
LANDGRAF, R
中科院分区：
文献类型：
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作者：
ENGELMANN, M;BURES, J;LANDGRAF, R
在27只Long-Evans系雄性大鼠上研究隔-海马系统加压素（AVP）在空间记忆中的作用。将大鼠植入隔微透析探针并分为3组。两天后，他们被训练在连续3天（12天的试验），以确定隐藏的水下平台在Morris水迷宫（MWM），而探针灌注与人工脑脊液（aCSF）或aCSF含有加压素或V1拮抗剂d（CH 2）5 Tyr（Me）AVP（AAVP）。另一组大鼠（n = 8）保持未处理。接受aCSF或AAVP微透析的组以与未处理动物相同的速率获得MWM任务。另一方面，位置导航学习显着受损AVP的微透析在所有会议期间。结果表明，内源性AVP（至少影响V1受体亚型）是不必要的收购空间记忆中的MWM，而过量存在的合成AVP干扰空间学习。
The role of vasopressin (AVP) in the septohippocampal system in spatial memory was studied in 27 male hooded rats of the Long-Evans strain. The rats were implanted with a septal microdialysis probe and assigned to 3 groups. Two days later, they were trained on 3 consecutive days (12 daily trials) to locate the hidden underwater platform in the Morris water maze (MWM) while the probes were perfused with either artificial cerebrospinal fluid (aCSF) or aCSF containing vasopressin or the V1 antagonist d(CH2)5Tyr(Me)AVP (AAVP). Another group of rats (n = 8) remained untreated. Groups receiving microdialysis of aCSF or AAVP acquired the MWM task at the same rate as untreated animals. On the other hand, place navigation learning was significantly impaired by microdialysis of AVP during all sessions. The results indicate that endogenous AVP (at least that affecting the V1 receptor subtype) is not indispensable for the acquisition of spatial memories in the MWM, whereas excessive presence of synthetic AVP interferes with spatial learning.