General and local toxicity of 5-hydroxymethyl-2-furfural in rabbits.
General and local toxicity of 5-hydroxymethyl-2-furfural in rabbits.
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DOI：
10.1111/j.1600-0773.1982.tb00944.x
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发表时间：
2009-03
期刊：
影响因子：
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通讯作者：
A. Rasmussen;I. Hessov;M. Bojsen-Møller
中科院分区：
文献类型：
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作者：
A. Rasmussen;I. Hessov;M. Bojsen-Møller
研究了5-羟甲基-2-呋喃甲醛(HMF)对兔的一般毒性(A)和静脉损伤特性(B)。每天两次皮下注射400毫克羟甲基纤维素钠，持续一周。与对照组相比，对体重、血红蛋白、白细胞、血小板、血清蛋白、血清丙氨酸氨基转移酶、碱性磷酸酶、肝细胞坏死或肝脂肪变性均无不良影响。加入200mg羟甲基纤维素钠/L等渗氯化钠溶液连续静脉滴注5h，对静脉刺激性无明显影响。这项研究中使用的羟甲基纤维素量远远超过患者从葡萄糖溶液中获得的量。
General toxicity (A) and vein damaging properties (B) of 5-hydroxymethyl-2-furfural (HMF) were studied in rabbits. A. 400 mg HMF was given as subcutaneous injections twice a day for a week. It was not possible to demonstrate any harmful effect of the injections on the following parameters: weight, haemoglobin, leucocytes, platelets, serum-protein, serum-alanine-aminotransferase, alkaline phosphatase, liver cell necrosis or hepatic steatosis as compared with a control group. B. Addition of 200 mg HMF/l isotonic NaCl solution did not increase the vein irritating effect of the solution, when given as a 5 hours' continuous intravenous infusion. The amounts of HMF used in this study far exceeded what patients receive from glucose solutions.