ABO blood group and risk of colorectal cancer.
ABO blood group and risk of colorectal cancer.
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DOI：
10.1158/1055-9965.epi-10-1250
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Chan AT
中科院分区：
文献类型：
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作者：
Khalili H;Wolpin BM;Huang ES;Giovannucci EL;Kraft P;Fuchs CS;Chan AT
最近的研究表明，非O血型与胰腺癌风险之间存在关联。目前尚不清楚这种关联是否与其他胃肠道恶性肿瘤，包括结直肠癌。我们在两个大的前瞻性队列中研究了ABO血型与结肠直肠癌发病风险之间的关系。我们使用考克斯比例风险模型计算风险比，同时调整已知的结直肠癌风险因素。在996,779人年的随访中，我们记录了1025例结直肠癌的发病病例。与O型血个体相比，A型血、B型血和AB型血的多变量校正风险比分别为1.08（95%置信区间[CI] 0.94-1.24）、1.20（95% CI，1.00-1.45）和1.08（95% CI，0.85-1.36）。在两个大型前瞻性队列中，我们没有观察到ABO血型与结直肠癌风险之间存在统计学显著相关性。这些结果不支持ABO血型与结直肠癌风险之间的关联。
Recent studies have shown an association between non-O blood group and risk of pancreatic cancer. It is unclear whether this association is observed with other gastrointestinal malignancies, including colorectal cancers. We examined the relationship between ABO blood group and the risk of incident colorectal cancer in two large prospective cohorts. We calculated hazard ratios using Cox proportional hazard modeling while adjusting for known risk factors of colorectal cancer. During 996,779 person-years of follow-up, we documented 1025 incident cases of colorectal cancers. Compared to individuals with blood group O, the multivariate-adjusted hazard ratios were 1.08 (95% confidence interval [CI] 0.94–1.24) for blood group A, 1.20 (95% CI, 1.00–1.45) for blood group B, and 1.08 (95% CI, 0.85–1.36) for blood group AB. In two large prospective cohorts, we did not observe a statistically significant association between ABO blood group and risk of colorectal cancer. These results do not support an association between ABO blood group and risk of colorectal cancer.