The FTO Gene and Measured Food Intake in 5-to 10-Year-Old Children Without Obesity
The FTO Gene and Measured Food Intake in 5-to 10-Year-Old Children Without Obesity
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DOI：
10.1002/oby.22464
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发表时间：
2019-06-01
期刊：
影响因子：
6.9
通讯作者：
Rosenbaum, Michael
中科院分区：
文献类型：
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作者：
Ranzenhofer, Lisa M.;Mayer, Laurel E. S.;Rosenbaum, Michael
目的 FTO 第一个内含子的遗传变异（例如单核苷酸多态性 [SNP] rs9939609）与肥胖密切相关。这种效应被认为是（至少部分）通过增加热量摄入来介导的，尽管精确的分子遗传机制尚未完全了解。此前对 FTO 的儿科研究包括超重和肥胖的青少年；然而，他们尚未得知在肥胖发生之前是否存在对摄入行为的基因型影响。因此，本研究调查了 5 至 10 岁非肥胖儿童的 FTO 与热量摄入之间的关系（肥胖
Objective Genetic variation in the first intron of FTO (e.g., single-nucleotide polymorphism [SNP] rs9939609) is strongly associated with adiposity. This effect is thought to be mediated (at least in part) via increasing caloric intake, although the precise molecular genetic mechanisms are not fully understood. Prior pediatric studies of FTO have included youth with overweight and obesity; however, they have not informed whether a genotypic effect on ingestive behavior is present prior to obesity onset. Therefore, this study investigated the association between FTO and caloric intake in children aged 5 to 10 years without obesity (adiposity