Lentiviral diseases of sheep and goats: chronic pneumonia leukoencephalomyelitis and arthritis.
Lentiviral diseases of sheep and goats: chronic pneumonia leukoencephalomyelitis and arthritis.
复制标题
绵羊和山羊的慢病毒病：慢性肺炎、白质脑脊髓炎和关节炎。
DOI：
10.1093/clinids/7.1.89
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Cork,LC
中科院分区：
文献类型：
--
作者：
Narayan,O;Cork,LC
本文综述了自然发生的非致癌性逆转录病毒引起的绵羊和山羊慢性进行性疾病的发病机制。在自然界中，感染通常在临床上是沉默的，但疾病可能在长时间的潜伏期后表现出来。临床上，这被视为呼吸困难、进行性瘫痪和/或进行性关节炎。在所有器官中，基本病变是炎性的，伴有淋巴细胞、浆细胞和巨噬细胞的浸润和增殖。其他器官特异性病理变化，如中枢神经系统的原发性脱髓鞘和关节软骨结构的变性伴随炎症。病毒在体内感染组织特异性巨噬细胞群体。这些细胞中的病毒复制被限制在最低水平，但由于未能诱导特异性中和抗体或中和抗体产生时抗原漂移，病毒复制在动物中无限期地持续。持续的低度病毒复制通过为炎症细胞免疫应答或定位于靶组织中的抗体提供持续的抗原刺激来设定疾病的速度。这些细胞和免疫复合物可能对固有细胞群产生不利影响。
This review describes the pathogenesis of a slowly progressive disease complex caused by naturally occurring nononcogenic retroviruses in sheep and goats. In nature, infections are usually clinically silent, but disease may manifest itself after prolonged incubation periods. Clinically, this is seen as dyspnea, progressive paralysis, and/or progressive arthritis. In all organs the basic lesion is inflammatory with infiltration and proliferation of lymphocytes, plasma cells, and macrophages. Other organ-specific pathologic changes such as primary demyelination in the central nervous system and degeneration of cartilaginous structures in joints accompany inflammation. The viruses infect tissue-specific macrophage populations in vivo. Viral replication in these cells is restricted to minimal levels but continues indefinitely in the animal as a result of either failure to induce specific neutralizing antibodies or antigenic drift when neutralizing antibodies develop. Consistent low-grade viral replication sets the pace for disease by providing continuous antigenic stimulation for the inflammatory cellular immune response or antibodies that localize in the target tissues. These cells and immune complexes may have adverse effects on indigenous cell populations.