dictyBase 2015: Expanding data and annotations in a new software environment.
dictyBase 2015: Expanding data and annotations in a new software environment.
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DOI：
10.1002/dvg.22867
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Chisholm RL
中科院分区：
文献类型：
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作者：
Basu S;Fey P;Jimenez-Morales D;Dodson RJ;Chisholm RL
dictyBase是群居变形虫盘形变形虫及其近缘种的模式生物数据库。dictyBase的主要任务是为生物医学研究界提供集成良好的高质量数据和工具，使原始研究成为可能。dictyBase提供的数据来自测序中心、进行高通量实验（如大规模诱变研究）的小组和RNAseq数据，以及越来越多的从已发表文献中手动添加的功能基因注释，包括基因本体、菌株和表型注释。通过Dicty库存中心，我们为社区提供了数量可观的带注释的菌株和质粒。最近，dictyBase完成了一项重大改革，使过时的基础设施适应当前的技术进步，从而促进了创新工具和比较基因组学的实施。它还提供了高质量注释的新策略，使工作台研究人员能够从快速增长的可用数据量中受益。dictyBase对用户的需求反应迅速，利用Dictyostelium研究社区的巨大努力建立了成功的关系。dictyBase已经成为Dictyostelium研究者、其他研究者或寻求Dictyostelium信息的组织以及使用该模型系统的教育工作者的可信数据资源。
dictyBase is the model organism database for the social amoeba Dictyostelium discoideum and related species. The primary mission of dictyBase is to provide the biomedical research community with well-integrated high quality data, and tools that enable original research. Data presented at dictyBase is obtained from sequencing centers, groups performing high throughput experiments such as large-scale mutagenesis studies, and RNAseq data, as well as a growing number of manually added functional gene annotations from the published literature, including Gene Ontology, strain, and phenotype annotations. Through the Dicty Stock Center we provide the community with an impressive amount of annotated strains and plasmids. Recently dictyBase accomplished a major overhaul to adapt an outdated infrastructure to the current technological advances, thus facilitating the implementation of innovative tools and comparative genomics. It also provides new strategies for high quality annotations that enable bench researchers to benefit from the rapidly increasing volume of available data. dictyBase is highly responsive to its users needs, building a successful relationship that capitalizes on the vast efforts of the Dictyostelium research community. dictyBase has become the trusted data resource for Dictyostelium investigators, other investigators or organizations seeking information about Dictyostelium, as well as educators who use this model system.