Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients
Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients
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DOI：
10.1126/science.276.5320.1851
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发表时间：
1997-06-20
期刊：
影响因子：
56.9
通讯作者：
Berenson, JR
中科院分区：
文献类型：
--
作者：
Rettig, MB;Ma, HJ;Berenson, JR
卡波西肉瘤相关疱疹病毒（KSHV）在多发性骨髓瘤患者的骨髓树突状细胞中发现，但在正常人或其他恶性肿瘤患者的恶性浆细胞或骨髓树突状细胞中未发现。此外，在8名患有未确定意义单克隆γ病（MGUS）（骨髓瘤的前体）的患者中，有2名患者的骨髓树突状细胞中检测到该病毒。病毒白细胞介素-6是骨髓瘤生长因子的人类同源物，在骨髓瘤骨髓树突状细胞中被发现转录。从MGUS到骨髓瘤的转化和恶性浆细胞的生长可能需要KSHV。
Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.