Regulation of cell signalling cascades by steroid hormones
Regulation of cell signalling cascades by steroid hormones
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DOI：
10.1002/jcb.20180
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发表时间：
2004-09-01
影响因子：
4
通讯作者：
Cheskis, BJ
中科院分区：
文献类型：
--
作者：
Cheskis, BJ
类固醇激素控制着细胞内环境稳定、增殖、分化和凋亡等多种重要的细胞功能。在过去几年中收集的证据表明，这种调节是由基因表达的直接控制（所谓的“转录”作用，由位于细胞核中的受体驱动）和细胞信号传导/磷酸化级联的调节（“核”作用，由位于细胞膜附近的受体介导）的复杂界面介导的。基因表达的调节通过配体依赖性受体结合靶基因启动子作为前起始复合物的一部分而发生，这导致染色质重塑并最终调节基因表达速率。类固醇介导的细胞信号调节不依赖于基因转录或蛋白质生物合成。这种现象的分子机制尚未完全了解。这篇综述将集中在最近的发展有关我们的理解的分子机制的类固醇激素的促核作用。(C)2004 Wiley-Liss，Inc.
Steroid hormones control a wide variety of cellular functions important for cell homeostasis, proliferation, differentiation, and apoptosis. Evidence collected in the last few years indicates that this regulation is mediated by a complex interface of direct control of gene expression (so-called "transcriptional" action, driven by receptors that are localized in cell nucleus) and by regulation of cell signaling/phosphorylation cascades ("extranuclear" action, mediated by receptors that are localized in close proximity to cellular membrane). Regulation of gene expression takes place via ligand-dependent receptor binding to target gene promoters as part of the preinitiation complex, which leads to chromatin remodeling and ultimately regulates the rate of gene expression. Steroid-mediated regulation of cell signaling does not depend on gene transcription or protein biosynthesis. The molecular mechanism of this phenomenon is not fully understood. This review will focus on recent developments related to our understanding of the molecular mechanism of the extranuclear action of steroid hormones. (C) 2004 Wiley-Liss, Inc.