INFLUENCE OF AGEING ON IN VIVO ELASTICITY OF HUMAN SKIN
INFLUENCE OF AGEING ON IN VIVO ELASTICITY OF HUMAN SKIN
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DOI：
10.1159/000211681
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发表时间：
1969-01-01
期刊：
影响因子：
--
通讯作者：
HOLT, PJL
中科院分区：
文献类型：
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作者：
GRAHAME, R;HOLT, PJL
到目前为止，还没有直接测量活组织中胶原变化的方法。事实上，唯一可以进行的观察是测量作为胶原代谢参数的羟脯氨酸的尿排泄。由于胶原蛋白的最典型特征之一是其非常大的拉伸强度，因此寻找其机械性能的变化作为其结构在健康和疾病中变化的可能指标是合乎逻辑的。为此，我们选择研究一个容易接近的富含胶原蛋白的器官，即皮肤的弹性特性。在这篇文章中，我们将描述一种由我们之一（RG）开发的测量人体皮肤弹性的新方法，并介绍在健康受试者中获得的结果，试图阐明衰老的过程，因为它会影响真皮胶原蛋白。
Up to the present time there has heen no direct method of measuring changes in collagen in living tissues. In fact, the only observation that can be made is the measurement of the urinary excretion of hydroxyproline as a parameter of collagen metabolism. Since one of the most characteristic features of collagen is its very great tensile strength, it is logical to look for a change in its mechanical properties as a possible index of change in its structure both in health and disease. We have chosen for this purpose to investigate the elastic properties of a readily accessible organ very rich in collagen, namely the skin. In this communication we will describe a new method of measuring human skin elasticity in vivodeveloped by one of us (RG) and present the results obtained in healthy subjects in an attempt to elucidate the process of ageing as it affects the dermal collagen.