Agenda for Sleep Research in Older Adults With Cancer: A Conference Report.
Agenda for Sleep Research in Older Adults With Cancer: A Conference Report.
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老年癌症患者睡眠研究议程：会议报告。
DOI：
10.1097/ncc.0000000000000464
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发表时间：
2018
期刊：
影响因子：
2.6
通讯作者：
Dean,GraceE
中科院分区：
文献类型：
--
作者：
Matthews,EllynE;Hacker,EileenDanaher;Otte,JulieL;Dean,GraceE
背景：睡眠问题在老年人中很常见，但往往被忽视，特别是在癌症的背景下。潜在的机制知之甚少，干预措施往往缺乏明确的科学基础。目的：这份报告的目的是使用定性和迭代审查程序检查由美国国立卫生研究院赞助的U13“床边到工作台”会议上提出的科学内容。需要对目前与老年癌症患者睡眠相关的科学问题进行分析，以指导护士科学家和临床医生寻找研究机会。方法：参加会议的肿瘤学护士科学家进行了分析/综合知识差距和研究机会的多步骤回顾程序。结果：这一领域的概念性问题包括缺乏标准的睡眠术语和总体概念模型的缺乏。方法论问题是睡眠/午睡测量不一致，以及在设计全面但可行的老年人研究方面面临复杂的操作挑战。基础和临床科学中的知识空白涉及睡眠和昼夜节律紊乱的细胞和分子机制，睡眠对不良结果的贡献，以及住院期间和从医院到家庭过渡期间睡眠紊乱的影响。结论：集中和跨学科的研究，促进对老年癌症人群睡眠健康的生物学和行为决定因素的概念性和可操作性的理解，可以为癌症相关睡眠昼夜节律紊乱的患者带来更有效、安全和有针对性的干预。实践应用：解决当前概念、方法和生理问题的研究可以导致对患有癌症相关睡眠昼夜节律紊乱的老年人进行更有效、更安全和更有针对性的护理。
Background:Sleep problems are common but often neglected in older adults, particularly in the context of cancer. Underlying mechanisms are poorly understood and interventions frequently lack a clear scientific basis.Objective:The objective of this report was to examine scientific content presented at a National Institutes of Health–sponsored U13 “Bedside to Bench” conference using a qualitative and iterative review procedure. Analysis of current scientific issues regarding sleep in older adults with cancer is needed to direct nurse scientists and clinicians toward research opportunities.Methods:A multistep review procedure for the analysis/synthesis of knowledge gaps and research opportunities was undertaken by oncology nurse scientists in attendance.Results:Conceptual problems in this area include the lack of standard sleep terminology and absence of an overarching conceptual model. Methodological problems are inconsistent sleep/napping measurement and complex operational challenges in designing comprehensive yet feasible studies in older adults. Knowledge gaps in basic and clinical science relate to cellular and molecular mechanisms that underlie sleep and circadian rhythm disturbances, contribution of sleep to adverse outcomes, and impact of disturbed sleep during hospitalization and the transition from hospital to home.Conclusions:Focused and interdisciplinary research that advances conceptual and operational understanding of biological and behavioral determinants of sleep health in the aging cancer population can lead to more effective, safe, and targeted interventions for those with cancer-related sleep-circadian disturbances.Implications for Practice:Research that addresses current conceptual, methodological, and physiological issues can lead to more effective, safe, and targeted care for older adults with cancer-related sleep-circadian disturbances.