Age at menopause and mortality in Japan: the Jichi Medical School Cohort Study
Age at menopause and mortality in Japan: the Jichi Medical School Cohort Study
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DOI：
10.2188/jea.16.161
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发表时间：
2006-07-01
影响因子：
4.7
通讯作者：
Kajii, Eiji
中科院分区：
文献类型：
--
作者：
Amagai, Yoko;Ishikawa, Shizukiyo;Kajii, Eiji
背景技术背景：虽然有几项研究报告了绝经早期死亡风险增加，但在日本没有研究探讨绝经年龄与死亡率之间的关系。本分析的目的是调查绝经年龄和全因死亡率之间的关系在Japanese.METHODS：研究对象是4,683绝经后女性的济济医学院队列研究，一项以人口为基础的前瞻性研究。基线数据是通过1992年4月至1995年7月在日本12个农村地区进行问卷调查和健康检查获得的。主要的结局指标是截至2002年12月31日的死亡证明中的全因死亡率。采用考克斯比例风险模型分析绝经年龄与死亡率的关系。结果：在平均9.2年的随访期内，共观察到215例死亡。在调整年龄、收缩压、血清总胆固醇水平、血清高密度脂蛋白胆固醇水平、糖尿病史、体重指数、吸烟习惯、饮酒习惯、婚姻状况、研究领域和更年期类型后，风险比全因死亡率（95%置信区间）为2.10（1.07-4.11）、0.68（0.36-1.26）、0.94（0.68-1.30）和1.17（0.63-2.20）对于绝经年龄小于40岁、40-44岁、50-54岁和55岁或更大的女性，结论：我们的数据表明，在日本，年龄小于40岁的绝经期增加了各种原因导致的死亡风险。
BACKGROUND: Although several studies have reported increased mortality risk with early menopause, there were no studies examining the relationship between age at menopause and mortality in Japan. The goal of this analysis is to investigate the relationship between age at menopause and all-cause mortality among the Japanese.METHODS: Study subjects were 4,683 postmenopausal females in the Jichi Medical School Cohort Study, a population-based prospective study. Baseline data were obtained by questionnaire and health checkups between April 1992 and July 1995 in 12 rural areas in Japan. Main outcome measures were all-cause mortality derived from death certificates up to December 31, 2002. Cox's proportional hazard models were used to analyze the association of age at menopause with mortality.RESULTS: A total of 215 deaths were observed during the average of 9.2 year follow-up period. After adjusting for age, systolic blood pressure, serum total cholesterol level, serum high density lipoprotein cholesterol level, history of diabetes mellitus, body mass index, smoking habits, alcohol drinking habits, marital status, study area, and types of menopause, the hazard ratios (95% confidence intervals) of all-cause mortality were 2.10 (1.07-4.11), 0.68 (0.36-1.26), 0.94 (0.68-1.30), and 1.17 (0.63-2.20) for females with a menopause at ages younger than 40 years, 40-44, 50-54, and 55 or older, respectively, relative to those with menopause at age 45-49 years.CONCLUSIONS: Our data suggest that menopause aged younger than 40 years increases the risk of death from all causes among the Japanese.