Coexistent Malnutrition Is Associated with Perturbations in Systemic and Antigen-Specific Cytokine Responses in Latent Tuberculosis Infection
Coexistent Malnutrition Is Associated with Perturbations in Systemic and Antigen-Specific Cytokine Responses in Latent Tuberculosis Infection
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DOI：
10.1128/cvi.00009-16
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发表时间：
2016-04-01
影响因子：
--
通讯作者：
Babu, Subash
中科院分区：
文献类型：
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作者：
Anuradha, Rajamanickam;Munisankar, Saravanan;Babu, Subash
营养不良，如低体重指数（BMI）所定义的，是活动性结核病（TB）发展的主要风险因素，尽管这种易感性的生物学基础仍然很难确定。为了验证营养不良是否会影响潜伏性TB（LTB）患者的全身和抗原特异性细胞因子水平，我们检查了LTB和低BMI（LBMI）患者的循环和TB抗原刺激的细胞因子水平，并将其与LTB和正常BMI（NBMI）患者进行了比较。LBMI与LTB共存的特点是循环中1型血水平降低（γ干扰素[IFN-γ]和肿瘤坏死因子α [TNF-α]），2型（白细胞介素-4 [IL-4]）、17型（IL-22）和其他促炎性细胞因子（IL-1 α、IL-1 β和IL-6）细胞因子，但其他2型（IL-5和IL-13）和调节性（IL-10和转化生长因子β [TGF-β]）细胞因子水平升高。此外，LBMI伴LTB与TB抗原诱导的IFN-γ、TNF-α、IL-6、IL-1 α和IL-1 β水平降低相关。最后，在LTB患者中，BMI值与TNF-α和IL-1 β水平呈显著正相关，BMI值与IL-2、IL-10和TGF-β水平呈显著负相关。因此，我们的数据显示，潜伏性TB与低BMI共存的特点是保护性细胞因子反应减弱和调节性细胞因子反应增强，这为活动性TB风险增加提供了潜在的生物学机制。
Malnutrition, as defined by low body mass index (BMI), is a major risk factor for the development of active tuberculosis (TB), although the biological basis underlying this susceptibility remains poorly characterized. To verify whether malnutrition affects the systemic and antigen-specific cytokine levels in individuals with latent TB (LTB), we examined circulating and TB antigen-stimulated levels of cytokines in individuals with LTB and low BMI (LBMI) and compared them with those in individuals with LTB and normal BMI (NBMI). Coexistent LBMI with LTB was characterized by diminished circulating levels of type 1 (gamma interferon [IFN-gamma] and tumor necrosis factor alpha [TNF-alpha]), type 2 (interleukin-4 [IL-4]), type 17 (IL-22), and other proinflammatory (IL-1 alpha, IL-1 beta, and IL-6) cytokines but elevated levels of other type 2 (IL-5 and IL-13) and regulatory (IL-10 and transforming growth factor beta [TGF-beta]) cytokines. In addition, LBMI with LTB was associated with diminished TB antigen-induced IFN-gamma, TNF-alpha, IL-6, IL-1 alpha, and IL-1 beta levels. Finally, there was a significant positive correlation between BMI values and TNF-alpha and IL-1 beta levels and a significant negative correlation between BMI values and IL-2, IL-10, and TGF-beta levels in individuals with LTB. Therefore, our data reveal that latent TB with a coexistent low BMI is characterized by diminished protective cytokine responses and heightened regulatory cytokine responses, providing a potential biological mechanism for the increased risk of developing active TB.