A population-specific correlation between ADIPOQ rs2241766 and rs 1501299 and colorectal cancer risk: a meta-analysis for debate
A population-specific correlation between ADIPOQ rs2241766 and rs 1501299 and colorectal cancer risk: a meta-analysis for debate
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DOI：
10.1007/s10147-016-1044-3
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发表时间：
2017-04
影响因子：
3.3
通讯作者：
Lin Ye;Guobin Wang;Yong Tang;Jie Bai
中科院分区：
文献类型：
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作者：
Lin Ye;Guobin Wang;Yong Tang;Jie Bai
许多流行病学研究探讨了脂联素、C1 Q和胶原结构域（ADIPOQ）单核苷酸多态性（SNPs）与结直肠癌（CRC）风险的关系。尽管已经报道了相互矛盾的结果，但对于两个SNP（rs 2241766 T/G和rs 1501299 G/T）存在争议。因此，我们进行了一项荟萃分析，系统地评估协会，并试图找到争议的原因.MethodsWe检索PubMed，科克伦图书馆，爱思唯尔，威利在线图书馆，中国国家知识基础设施，万方数据和重庆维普搜索所有合格的病例对照研究发表到2015年1月。使用固定或随机效应模型计算效应大小的比值比（OR）和95%置信区间（95%CI）。rs 2241766在中国人（OR 0.76; 95% CI 0.68，0.85;P< 0.001）和德系犹太人（OR 0.79; 95% CI 0.63，0.99;P= 0.04）中具有显性模型（TT vs TG + GG），观察到显著差异。rs 1501299在中国人群中具有显著性差异（OR 1.23; 95% CI 1.11，1.37;P< 0.001），具有显性模型（TT vs TG + GG）。结论ADIPOQ基因rs 2241766 T/G和rs 1501299 G/T单核苷酸多态性与结直肠癌（CRC）的发病风险具有群体特异性相关性。然而，小样本研究可能会增加报告偏倚，特别是如果分析中包含的研究总数很少。
AimsMany epidemiological studies have investigated the correlation between adiponectin, C1Q and collagen domain containing (ADIPOQ) single nucleotide polymorphisms (SNPs) and risk of colorectal cancer (CRC). Although conflicting results have been reported, there was dispute regarding two SNPs (rs2241766 T/G and rs1501299 G/T). Therefore, we conducted a meta-analysis to systematically assess the associations and try to find the reasons for the dispute.MethodsWe searched PubMed, the Cochrane Library, Elsevier, Wiley Online Library, China National Knowledge Infrastructure, WanFang data and Chongqing VIP to search for all eligible case−control studies published up to January 2015. Effect sizes of odds ratios (OR) and 95 % confidence intervals (95 % CI) were calculated using a fixed- or random-effect model.ResultsTen case–control studies including 4377 cases and 5584 controls were selected. A significant difference was observed in Chinese (OR 0.76; 95 % CI 0.68, 0.85;P< 0.001) and Ashkenazi Jewish populations (OR 0.79; 95 % CI 0.63, 0.99;P= 0.04) for rs2241766 with dominant model (TT vs TG + GG). A significant difference was observed in the Chinese population (OR 1.23; 95 % CI 1.11, 1.37;P< 0.001) for rs1501299 with dominant model (TT vs TG + GG). In addition, intake of red meat showed a synergistic effect between ADIPOQ gene and risk of colorectal cancer (CRC).ConclusionsADIPOQ SNPs rs2241766 T/G and rs 1501299 G/T have a population-specific correlation with risk of CRC. However, small sample studies may increase reporting bias, particularly if the total number of studies included in the analysis is small.