Anti-CENP-H antibodies in patients with Sjogren's syndrome
Anti-CENP-H antibodies in patients with Sjogren's syndrome
复制标题
DOI：
10.1007/s00296-004-0568-4
复制
发表时间：
2006-02-01
影响因子：
4
通讯作者：
Tsay, GJ
中科院分区：
文献类型：
--
作者：
Hsu, TC;Chang, CH;Tsay, GJ
抗着丝粒抗体（ACA）已被报道与干燥综合征（SS）有关，抗CENP-H抗体的临床意义尚不清楚。为探讨抗CENP-H和抗着丝粒抗体在原发性SS中的临床意义，采用酶联免疫吸附试验（ELISA）和间接免疫荧光法（IIF）分别检测了62例原发性SS患者和40例正常人血清中的抗SS-A/SS-B抗体、ACA和抗CENP-H抗体。在62例原发性SS患者中，17例ACA和抗CENP-H抗体阳性。具有抗CENP-H和ACA抗体的SS患者的血清不含抗SS-A/Ro和/或抗SS-B/La抗体。正常人血清中未发现抗CENP-H抗体。在SS患者中首次发现ACA和抗CENP-H抗体的频率增加。抗CENP-H抗体和抗SS-A/Ro或抗SS-B/La抗体是互斥的。抗CENP-H抗体患者类风湿因子（RF）的频率较低。SS在血清学上可分为两组：第一组为抗SS-A/Ro和/或抗SS-B/La抗体，第二组为ACA和/或抗CENP-H抗体。我们建议ACA或抗CENP-H抗体应作为SS的血清学标志物之一。
Anti-centromere antibody (ACA) has been reported to be associated with Sjogren's syndrome (SS) and the clinical significance of anti-CENP-H antibody remains unknown. To determine the clinical significance of anti-CENP-H and anti-centromere antibodies in primary SS, sera from 62 patients with primary SS and 40 normal controls were examined for anti-SS-A/SS-B antibodies, ACA and anti-CENP-H antibodies, by enzyme-linked immunosorbent assay and indirect immunofluorescence (IIF), respectively. Of the 62 serum samples with primary SS, 17 were positive with ACA and anti-CENP-H antibodies. Sera from SS patients with anti-CENP-H and ACA antibodies do not contain anti-SS-A/Ro and/or anti-SS-B/La antibodies. No anti-CENP-H antibody was found in sera of normal controls. An increased frequency of ACA and anti-CENP-H antibodies was found for the first time in patients with SS. Anti-CENP-H antibodies and anti-SS-A/Ro or anti-SS-B/La antibodies are present mutually exclusive. Patients with anti-CENP-H antibodies had a lower frequency of rheumatoid factor (RF). SS can be subdivided serologically into two groups; group one with anti-SS-A/Ro and/or anti-SS-B/La antibody, group two with ACA and/or anti-CENP-H antibodies. We recommend that ACA or anti-CENP-H antibodies should be considered as one of the serological markers for SS.