CELLULAR LIPID-BINDING PROTEINS - EXPRESSION, FUNCTION, AND NUTRITIONAL REGULATION
CELLULAR LIPID-BINDING PROTEINS - EXPRESSION, FUNCTION, AND NUTRITIONAL REGULATION
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DOI：
10.1096/fasebj.3.13.2680704
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发表时间：
1989-11-01
期刊：
影响因子：
4.8
通讯作者：
ARMSTRONG, MK
中科院分区：
文献类型：
--
作者：
CLARKE, SD;ARMSTRONG, MK
疏水性配体（包括固醇、脂肪酸、类维生素A和某些疏水性致癌物）的膜转运和胞质溶解由一组类似的低分子量蛋白促进：质膜转运蛋白、脂肪酸结合蛋白、固醇载体蛋白和类维生素A结合蛋白。这些蛋白质的细胞含量，其建立了细胞利用各种配体的能力，由调节转录和翻译的事件决定，例如，肝脏和肠道型FABP的mRNA丰度通过膳食脂肪增加，并且肝脏FABP的翻译似乎受到胰岛素的刺激。这些脂质结合蛋白的功能尚不清楚，但数据显示其在1）脂肪酸转运、酯化和氧化，2）类固醇生成和3）类维生素A摄取、视黄醇还原和视黄醇酯化中的生理作用。一个令人兴奋的和新的前景的细胞运输蛋白是他们可能发挥的作用，在调节基因表达。在这方面，细胞脂质结合蛋白，例如，类维生素A结合蛋白可将其配体递送至核反式作用蛋白，从而调节编码参与脂质代谢或分化的关键蛋白的基因。尽管这些蛋白质的功能仍然需要明确确定，但很明显，它们在脂质代谢的整体稳态中很重要。Clarke，S. D.的;阿姆斯特朗，M。K. Cellular lipid binding proteins：expression，function，and nutritional regulation.FASEB J.3：2480 - 2487; 1989.
The membrane transport and cytosolic solubilization of hydrophobic ligands, including sterols, fatty acids, retinoids, and certain hydrophobic carcinogens, are facilitated by a group of similar low molecular weight proteins: plasma membrane transport protein, fatty acid binding proteins, sterol carrier protein, and retinoid binding proteins. The cellular content of these proteins, which establishes the capacity of a cell to utilize the various ligands, is determined by events regulating transcription and translation, e.g., the mRNA abundance of liver‐ and gut‐type FABPs is increased by dietary fat, and translation of hepatic FABP appears to be stimulated by insulin. Functions attributable to these lipid binding proteins remain unclear, but data are presented that indicate physiological roles in1) fatty acid transport, esterification, and oxidation,2) steroidogenesis, and3) retinoid uptake, retinaldehyde reduction, and retinol esterification. An exciting and novel prospect for cellular trafficking proteins is the role they may play in regulating gene expression. In this respect, cellular lipid binding proteins, e.g., retinoid binding proteins, may deliver their ligands to nucleartrans‐acting proteins, and thereby modulate genes coding for key proteins involved in lipid metabolism or differentiation. Even though the functions of these proteins still need to be unequivocally established, it is clear that they are important in the overall homeostasis of lipid metabolism.—Clarke, S. D.; Armstrong, M. K. Cellular lipid binding proteins: expression, function, and nutritional regulation.FASEB J.3: 2480‐2487; 1989.