Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank
Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank
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髋部 DXA 扫描上骨赘的大小和位置与髋部疼痛相关：英国生物银行横断面研究的结果
DOI：
10.1101/2021.04.26.21255905
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Faber B
中科院分区：
文献类型：
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作者：
Faber B
目的目前尚不清楚放射学髋骨关节炎（rHOA）的不同特征如何导致髋部疼痛。我们使用基于双能 X 射线吸收测定法 (DXA) 的新型方法检查了 rHOA（包括其各个成分）与髋部疼痛之间的关系。方法髋部 DXA 获自英国生物银行。一种新颖的自动化方法从股骨头和髋臼周围的点获得最小关节间隙宽度（mJSW）。手动获取外侧髋臼、上股骨头和下股骨头的骨赘区域。结合骨赘和关节间隙狭窄 (JSN) 的半定量测量来定义 rHOA。使用逻辑回归来检查这些变量与通过问卷获得的髋部疼痛之间的关系。结果检查了 6807 名髋部 DXA。 rHOA 存在于 353 名 (5.2%) 个体中，并且与髋部疼痛 [OR 2.42 (1.78–3.29)] 和医院诊断的 OA [6.01 (2.98–12.16)] 相关。在相互调整的模型中，骨赘总面积而非 mJSW 与髋部疼痛相关[分别为 1.31 (1.23–1.39)、0.95 (0.87–1.04)]。另一方面，JSN 作为分类变量显示 ≥ 1 级和 ≥ 2 级 JSN 与髋部疼痛之间的关联较弱 [分别为 1.30 (1.06–1.60)、1.80 (1.34–2.42)]。髋臼、股骨上、下骨赘面积均与髋部疼痛独立相关[分别为 1.13 (1.06–1.20)、1.13 (1.05–1.24)、1.10 (1.03–1.17)]。 结论 在该队列中，rHOA 与普遍髋部疼痛之间的关系可以通过二维骨赘面积来解释，但不能通过表观 mJSW 来解释。不同位置的骨赘显示出与髋部疼痛重要的、潜在独立的关联，可能反映了不同生物力学途径的贡献。
ObjectiveIt remains unclear how the different features of radiographic hip osteoarthritis (rHOA) contribute to hip pain. We examined the relationship between rHOA, including its individual components, and hip pain using a novel dual-energy x-ray absorptiometry (DXA)-based method.MethodsHip DXAs were obtained from UK Biobank. A novel automated method obtained minimum joint space width (mJSW) from points placed around the femoral head and acetabulum. Osteophyte areas at the lateral acetabulum, superior and inferior femoral head were derived manually. Semi-quantitative measures of osteophytes and joint space narrowing (JSN) were combined to define rHOA. Logistic regression was used to examine the relationships between these variables and hip pain, obtained via questionnaires.Results6807 hip DXAs were examined. rHOA was present in 353 (5.2%) individuals and was associated with hip pain [OR 2.42 (1.78–3.29)] and hospital diagnosed OA [6.01 (2.98–12.16)]. Total osteophyte area but not mJSW was associated with hip pain in mutually adjusted models [1.31 (1.23–1.39), 0.95 (0.87–1.04) respectively]. On the other hand, JSN as a categorical variable showed weak associations between grade ≥ 1 and grade ≥ 2 JSN with hip pain [1.30 (1.06–1.60), 1.80 (1.34–2.42) respectively]. Acetabular, superior and inferior femoral osteophyte areas were all independently associated with hip pain [1.13 (1.06–1.20), 1.13 (1.05–1.24), 1.10 (1.03–1.17) respectively].ConclusionIn this cohort, the relationship between rHOA and prevalent hip pain was explained by 2-dimensional osteophyte area, but not by the apparent mJSW. Osteophytes at different locations showed important, potentially independent, associations with hip pain, possibly reflecting the contribution of distinct biomechanical pathways.