SEX-DIFFERENCES AND THE EFFECT OF GONADECTOMY ON MORPHINE-INDUCED ANTINOCICEPTION AND DEPENDENCE IN RATS AND MICE
SEX-DIFFERENCES AND THE EFFECT OF GONADECTOMY ON MORPHINE-INDUCED ANTINOCICEPTION AND DEPENDENCE IN RATS AND MICE
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DOI：
10.1111/j.1440-1681.1995.tb02012.x
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发表时间：
1995-05-01
影响因子：
2.9
通讯作者：
ELKADI, A
中科院分区：
文献类型：
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作者：
ALI, BH;SHARIF, SI;ELKADI, A
1.在大鼠和小鼠中研究了性别之间的差异以及双侧手术性腺切除对吗啡镇痛和依赖反应的影响。通过热板和腹部收缩试验评估对吗啡（5 mg/kg）的镇痛反应。连续6天递增剂量（5-160 mg/kg）注射吗啡诱导依赖，注射纳洛酮（2.5 mg/kg）诱导戒断症状.正常对照组、假手术组和去性腺组动物的基线反应时在性别上均无显著差异.经吗啡处理后，去性腺大鼠、雌性大鼠和去性腺雄性小鼠的反应时增加百分比均显著高于各自的对照组.吗啡处理后，雌性大鼠的反应时间增加显著高于雄性大鼠。吗啡依赖性性腺切除大鼠和小鼠中纳洛酮诱导的戒断体征与假手术对照组无显著差异。然而，两组中的雌性大鼠比雄性大鼠表现出更高数量的逃避跳跃反应。
1. Differences between sexes and the effect of bilateral surgical gonadectomy on the response to morphine analgesia and dependence were examined in rats and mice.2. The analgesic response to morphine (5 mg/kg) was assessed by the hot plate and the abdominal constriction tests. Dependence was induced by injecting morphine at increasing doses (5-160 mg/kg) for 6 consecutive days and withdrawal signs elicited by injecting naloxone (2.5 mg/kg).3. The base line reaction times in the intact control, sham-operated and gonadectomized animals of either sex were not significantly different from each other.4. After treatment with morphine, the percentage increase in the reaction time in gonadectomized male and female rats and in gonadectomized male mice was significantly higher than in their respective controls.5. The increase in the reaction time, after morphine treatment, was significantly higher in gonadectomized female rats than in gonadectomized male rats.6. Naloxone-induced withdrawal signs in morphine-dependent gonadectomized rats and mice were not significantly different from those in sham-operated controls. However, female rats in both groups exhibited a significantly higher number of escape jumping responses than males.