Protein Resistance Driven by Polymer Nanoarchitecture
Protein Resistance Driven by Polymer Nanoarchitecture
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DOI：
10.1021/acsmacrolett.9b00518
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发表时间：
2019-09-01
影响因子：
7.015
通讯作者：
Koga, Tadanori
中科院分区：
文献类型：
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作者：
Endoh, Maya K.;Morimitsu, Yuma;Koga, Tadanori
我们报告说，与表面化学相比，高分子链的纳米级结构对其蛋白质抗性起着至关重要的作用。蛋白质排斥(不带电)，设计了几个纳米厚的聚合物层，均聚物链物理吸附在固体上。我们评价了亲水或疏水吸附的均聚物链对水中牛血清白蛋白的防污性能。分子动力学模拟结合和频产生光谱数据揭示了由内向列型有序链段和外刷型链段组成的吸附链在均聚体系中的自组织纳米结构，这些均聚体系具有不同的聚合物、基质和界面水之间的相互作用。我们认为这种结构是阻止蛋白质吸附的双重屏障。
We report that the nanometer-scale architecture of polymer chains plays a crucial role in its protein resistant property over surface chemistry. Protein-repellent (noncharged), few nanometer thick polymer layers were designed with homopolymer chains physisorbed on solids. We evaluated the antifouling property of the hydrophilic or hydrophobic adsorbed homopolymer chains against bovine serum albumin in water. Molecular dynamics simulations along with sum frequency generation spectroscopy data revealed the self-organized nanoarchitecture of the adsorbed chains composed of inner nematic-like ordered segments and outer brush-like segments across homopolymer systems with different interactions among a polymer, substrate, and interfacial water. We propose that this structure acts as a dual barrier against protein adsorption.