The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase
The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase
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DOI：
10.1101/cshperspect.a016675
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发表时间：
2014-10-01
影响因子：
7.2
通讯作者：
Hochwagen, Andreas
中科院分区：
文献类型：
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作者：
Subramanian, Vijayalakshmi V.;Hochwagen, Andreas
通过减数分裂产生单倍体配子对于有性繁殖生物体来说是一个高度保守的过程，在几乎所有的情况下，都涉及到染色体的广泛破坏。这些染色体断裂发生在减数分裂前期，对于减数分裂重组以及随后同源染色体的分离是必不可少的。然而，它们的形成和修复必须根据核动力学和细胞分裂程序进行仔细的监测和设计，以避免产生异常的染色体和有缺陷的配子。越来越清楚的是，与典型的DNA损伤反应相关的复杂的检查点信号网络与减数分裂程序深度交织在一起，并在减数分裂前期维持秩序。这种减数分裂检查点网络(MCN)建立了广泛的依赖关系，控制着染色体运动、染色体配对、染色质结构和双链断裂(DSB)修复。在这篇综述中，我们总结了我们目前对MCN的理解。我们讨论不同实验系统中的共性和差异，特别强调控制和限制信号之间串扰的新兴设计原则，以最终确保下一代染色体的忠实遗传。
The generation of haploid gametes by meiosis is a highly conserved process for sexually reproducing organisms that, in almost all cases, involves the extensive breakage of chromosomes. These chromosome breaks occur during meiotic prophase and are essential for meiotic recombination as well as the subsequent segregation of homologous chromosomes. However, their formation and repair must be carefully monitored and choreographed with nuclear dynamics and the cell division program to avoid the creation of aberrant chromosomes and defective gametes. It is becoming increasingly clear that an intricate checkpoint-signaling network related to the canonical DNA damage response is deeply interwoven with the meiotic program and preserves order during meiotic prophase. This meiotic checkpoint network (MCN) creates a wide range of dependent relationships controlling chromosome movement, chromosome pairing, chromatin structure, and double-strand break (DSB) repair. In this review, we summarize our current understanding of the MCN. We discuss commonalities and differences in different experimental systems, with a particular emphasis on the emerging design principles that control and limit cross talk between signals to ultimately ensure the faithful inheritance of chromosomes by the next generation.