Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use.
Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use.
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DOI：
10.1038/s41598-021-85283-6
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发表时间：
2021-03-15
影响因子：
4.6
通讯作者：
Ibrahim S
中科院分区：
文献类型：
--
作者：
Butt AA;Yan P;Kapadia S;Abou-Samra AB;Janjua NZ;Ibrahim S
处方阿片类药物使用（POU）往往是阿片类药物使用障碍（OUD）和随后的后果的前兆。慢性丙型肝炎病毒感染（CHC）的人可能由于更高的合并症负担和社会易感性因素而具有更高的POU风险。我们试图确定在社会脆弱性背景下CHC患者的POU负担和相关风险因素。我们在电子检索的HCV感染退伍军人队列中确定了CHC患者和倾向评分匹配的HCV-对照，并确定了急性、发作性长期和慢性长期POU的频率以及POU患者中社会易损性因素的患病率。我们使用逻辑回归分析来确定与POU相关的因素。160,856例CHC和160,856例倾向评分匹配的hcv对照组中，急性POU发生率分别为38.4%和38.0% （P = 0.01）。两组发作性长期POU发生率分别为3.9% (P = 0.5)，慢性长期POU发生率分别为28.4%和19.2% （P < 0.0001）。CHC与慢性长期POU的高风险相关（OR 1.66, 95%CI 1.63, 1.69），但与急性或发作性长期POU无关。黑人种族、女性性别和无家可归与慢性长期POU的高风险相关。≥1个因素的存在与所有POU类型的高风险相关。CHC患者社会脆弱性因素较多，慢性长期POU风险较高。存在≥1个社会脆弱性因素与POU的高风险相关。POU的下游影响需要进一步研究。
Prescription opioid use (POU) is often a precursor to opioid use disorder (OUD) and subsequent consequences. Persons with chronic hepatitis C virus infection (CHC) may be at a higher risk of POU due to a higher comorbidity burden and social vulnerability factors. We sought to determine the burden of POU and associated risk factors among persons with CHC in the context of social vulnerability. We identified CHC persons and propensity-score matched HCV− controls in the electronically retrieved Cohort of HCV-Infected Veterans and determined the frequency of acute, episodic long-term and chronic long-term POU and the prevalence of social vulnerability factors among persons with POU. We used logistic regression analysis to determine factors associated with POU. Among 160,856 CHC and 160,856 propensity-score matched HCV-controls, acute POU was recorded in 38.4% and 38.0% (P = 0.01) respectively. Episodic long-term POU was recorded in 3.9% in each group (P = 0.5), while chronic long-term POU was recorded in 28.4% and 19.2% (P < 0.0001). CHC was associated with a higher risk of chronic long-term POU (OR 1.66, 95%CI 1.63, 1.69), but not with acute or episodic long-term POU. Black race, female sex and homelessness were associated with a higher risk of chronic long-term POU. Presence of ≥ 1 factor was associated with a higher risk of all POU patterns. Persons with CHC have more social vulnerability factors and a higher risk of chronic long-term POU. Presence of ≥ 1 social vulnerability factor is associated with a higher risk of POU. Downstream consequences of POU need further study.
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影响因子：
158.5
作者：
Alter, MJ;Kruszon-Moran, D;Margolis, HS
通讯作者：
Margolis, HS
影响因子：
4.5
作者：
Chirikos, Thomas N.;Roetzheim, Richard G.;Iezzoni, Lisa I.
通讯作者：
Iezzoni, Lisa I.
影响因子：
3.1
作者：
Lovejoy, Travis I.;Dobscha, Steven K.;Morasco, Benjamin J.
通讯作者：
Morasco, Benjamin J.
影响因子：
2.5
作者：
Chen JY;Ren Y;Yan P;Belina ME;Chung RT;Butt AA
通讯作者：
Butt AA
影响因子：
29.4
作者：
Butt, Adeel A.;Yan, Peng;Freiberg, Matthew S.
通讯作者：
Freiberg, Matthew S.