Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles
Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles
复制标题
DOI：
10.4155/fmc.12.57
复制
发表时间：
2012-06-01
影响因子：
4.2
通讯作者：
Chikhalia, Kishor H.
中科院分区：
文献类型：
--
作者：
Patel, Rahul V.;Kumari, Premlata;Chikhalia, Kishor H.
背景：微生物对抗菌药物库产生耐药性是对公共卫生的威胁。世卫组织最近的一份报告估计，2009年有130万艾滋病毒阴性患者和38万艾滋病毒阳性患者死于结核病。各种形式的癌症在妇女（乳腺癌）和男子（前列腺癌）的死亡中所占比例很高。结果与讨论：新构建的s-三嗪类化合物对包括细菌、真菌和分枝杆菌在内的一组微生物的体外活性评估表明，这些化合物对即将发现的药物具有巨大的吸引力。进一步检测了它们对乳腺癌和前列腺癌细胞系以及HIV-1 （IIIB）和HIV-2 （ROD）病毒株的体外活性。通过IR， H-1 NMR, C-13 NMR， F-19 NMR波谱和元素分析对其结构进行了证实。结论：这些产物的活性谱可能对未来的药物发现研究有很大的帮助。
Background: The acquirement of resistance by microorganisms to the antimicrobial arsenal is a threat to public health. A recent WHO report estimated that 1.3 million HIV-negative people and 0.38 million HIV-positive people died from TB in 2009. Various forms of cancer account for a high percentage of deaths in both women (breast cancer) and men (prostate cancer). Results & discussion: In vitro activity assessment of newly constructed s-triazines against a panel of microorganisms including bacteria, fungi and Mycobacteria demonstrated that the compounds are of immense attraction for impending drug discovery. They were further examined for in vitro activity against breast cancer and prostate cancer cell lines, as well as HIV-1 (IIIB) and HIV-2 (ROD) viral strains. Proposed structural confirmation studies by IR, H-1 NMR, C-13 NMR, F-19 NMR spectroscopy and elemental analysis were in accordance. Conclusion: Activity profiles of the products may contribute considerably to future drug-discovery studies.