Mucosal Perfusion Preservation by a Novel Shapeable Tissue Expander for Oral Reconstruction.
Mucosal Perfusion Preservation by a Novel Shapeable Tissue Expander for Oral Reconstruction.
复制标题
用于口腔重建的新型可塑形组织扩张器保留粘膜灌注。
DOI：
10.1097/gox.0000000000001449
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Barco,ClarkT
中科院分区：
文献类型：
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作者：
Barwinska,Daria;Garner,John;Davidson,DarrellD;Cook,ToddG;Eckert,GeorgeJ;Tholpady,SunilS;March,KeithL;Park,Kinam;Barco,ClarkT
背景：目前用于扩张口腔粘膜的方法很少，且这些方法常引起组织坏死和扩张器出疹等并发症。本研究检查了插入新型可塑形水凝胶组织扩张器（HTE）后的粘膜血液灌注。犬模型采用拔牙和牙槽骨复位后龈下插入HTE。本研究的主要目的是了解上皮灌注和修复反应的牙龈粘膜在HTE expandment.Methods：9只比格犬进行了双侧前磨牙上颌和下颌牙拔除。三到四个月后，将HTE轮廓的插入物粘膜下植入牙槽嵴的颊面下。取出后，经过6- 7个月的愈合期，在相同部位插入新的HTE种植体。每周评估该区域的组织灌注和扩张体积。在扩张器remove.Results的时间进行活检组织学分析：在2周内第二次插入后，血流恢复到基线（定义为术前评估的灌注测量值），并保持正常，直到水凝胶完全扩张和删除。体积膨胀分析显示，水凝胶的体积加倍。组织学评估显示粘膜无巨噬细胞或炎性浸润。没有浅表纤维化，减少血管，或粘膜的变化是seeing.Conclusion：维持足够的组织灌注是一个临床上重要的方面，组织扩张器的性能，以减少设备损失或损伤的风险，病人，特别是对有历史的地区以前的手术。
Background: There are few methods for expanding oral mucosa, and these often cause complications such as tissue necrosis and expander eruption. This study examines mucosal blood perfusion following insertion of a novel shapeable hydrogel tissue expander (HTE). The canine model used subgingival insertion of HTE following tooth extraction and alveolar bone reduction. The primary goal of this study was to gain understanding of epithelial perfusion and reparative responses of gingival mucosa during HTE expansion.Methods: Nine Beagle dogs underwent bilateral premolar maxillary and mandibular tooth extraction. Three to four months later, HTE-contoured inserts were implanted submucosally under the buccal surface of the alveolar ridge. After removal and following a 6-to 7-month period of healing, new HTE implants were inserted at the same sites. The area was assessed weekly for tissue perfusion and volume of expansion. Biopsies for histological analysis were performed at the time of expander removal.Results: Within 2 weeks following the second insertion, blood flow returned to baseline (defined as the values of perfusion measurements at the presurgery assessment) and remained normal until hydrogel full expansion and removal. Volume expansion analysis revealed that the hydrogel doubled in volume. Histological assessment showed no macrophage or inflammatory infiltration of the mucosa. No superficial fibrosis, decreased vascularity, or mucosal change was seen.Conclusion: Maintenance of adequate tissue perfusion is a clinically important aspect of tissue expander performance to reduce risk of device loss or injury to the patient, particularly for areas with a history of previous surgeries.