EXPERIMENTAL CEREBRAL ISCHEMIA IN MONGOLIAN GERBILS .4. BEHAVIOR OF BIOGENIC-AMINES
EXPERIMENTAL CEREBRAL ISCHEMIA IN MONGOLIAN GERBILS .4. BEHAVIOR OF BIOGENIC-AMINES
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DOI：
10.1007/bf00685142
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发表时间：
1976-01-01
影响因子：
12.7
通讯作者：
KLATZO, I
中科院分区：
文献类型：
--
作者：
MRSULJA, BB;MRSULJA, BJ;KLATZO, I
本文研究了单侧颈总动脉阻断后蒙古沙鼠脑内生物胺的行为。对闭塞同侧半球的测定显示，在缺血性损伤的整个持续时间内，去甲肾上腺素和多巴胺逐渐减少，血清素[5-羟色胺]增加。在释放夹子后的缺血后时期，生物胺水平的变化通常符合先前描述的成熟现象的原理，在较短的缺血性损伤后发生延迟反应。
Behavior of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin [5-hydroxytryptamine] throughout the duration of an ischemic insult. In post-ischemic periods following the release of the clip, changes in biogenic amine levels generally conformed to the principles of a previously described maturation phenomenon, with delayed reactions occurring after the shorter ischemic insults.