A Selectfluor-promoted oxidative reaction of disulfides and amines: access to sulfinamides.
A Selectfluor-promoted oxidative reaction of disulfides and amines: access to sulfinamides.
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DOI：
10.1039/d0ob00720j
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发表时间：
2020-05
影响因子：
3.2
通讯作者：
Haibo Mei;Jiang Liu;Romana Pajkert;G. Röschenthaler;Jianlin Han
中科院分区：
文献类型：
--
作者：
Haibo Mei;Jiang Liu;Romana Pajkert;G. Röschenthaler;Jianlin Han
以选择性氟作为温和氧化剂，在有氧条件下进行了一种前所未有的无过渡金属氧化反应。该反应在温和的条件下进行，可耐受多种偶联伙伴，包括二硫化物和胺，以良好的化学收率生产相应的亚砜酰胺产品。此外，该反应可用于克级合成。该反应丰富了Selectfluor的研究内容，为方便合成亚胺类化合物提供了有价值的前景。
An unprecedented transition-metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed. This reaction was conducted under mild conditions and tolerated a wide range of coupling partners including disulfides and amines, affording the corresponding sulfinamide products in good chemical yields. Furthermore, this reaction could be used in gram-scale synthesis. This reaction enriches the research content of Selectfluor and provides a valuable vista for the convenient synthesis of sulfinamides.