Walking and dementia in physically capable elderly men
Walking and dementia in physically capable elderly men
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DOI：
10.1001/jama.292.12.1447
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发表时间：
2004-09-22
影响因子：
120.7
通讯作者：
Petrovitch, H
中科院分区：
文献类型：
--
作者：
Abbott, RD;White, LR;Petrovitch, H
背景证据表明，体力活动可能与痴呆的临床表现有关。该关联是否包括步行等低强度活动尚不清楚。目的探讨步行与老年男性未来患痴呆症风险之间的关联。设计前瞻性队列研究。背景和参与者1991年至1993年，在檀香山-亚洲老龄化研究中，对2257名71至93岁的身体健康男性进行了每天步行距离的评估。事件痴呆的后续行动是基于神经系统评估在2个重复examinations（1994-1996年和1997-1999年）。主要成果措施总体痴呆，阿尔茨海默病，血管性dementia.Results在随访过程中，158例痴呆症（15.6/ 1000人年）。在调整年龄后，步行最少（2英里/天）的男性，在步行0.25至1英里/天的人群中也观察到痴呆症的过度风险（17.6 vs 10.3/1000人年; RH，1.71; 95% CI，1.02-2.86）。这些协会持续占其他因素后，包括可能性，即有限的步行量可能是由于临床前dementions. Conclusions的身体功能下降的结果，研究结果表明，步行与痴呆症的风险降低。促进身体健康的男性积极的生活方式可以帮助晚年的认知功能。
Context Evidence suggests that physical activity may be related to the clinical expression of dementia. Whether the association includes low-intensity activity such as walking is not known.Objective To examine the association between walking and future risk of dementia in older men.Design Prospective cohort study.Setting and Participants Distance walked per day was assessed from 1991 to 1993 in 2257 physically capable men aged 71 to 93 years in the Honolulu-Asia Aging Study. Follow-up for incident dementia was based on neurological assessment at 2 repeat examinations (1994-1996 and 1997-1999).Main Outcome Measures Overall dementia, Alzheimer disease, and vascular dementia.Results During the course of follow-up, 158 cases of dementia were identified (15.6/ 1000 person-years). After adjusting for age, men who walked the least (2 mile/d), an excess risk of dementia was also observed in those who walked 0.25 to 1 mile/d (17.6 vs 10.3/1000 person-years; RH, 1.71; 95% Cl, 1.02-2.86). These associations persisted after accounting for other factors, including the possibility that limited amounts of walking could be the result of a decline in physical function due to preclinical dementia.Conclusions Findings suggest that walking is associated with a reduced risk of dementia. Promoting active lifestyles in physically capable men could help late-life cognitive function.