PLACE CELLS, HEAD DIRECTION CELLS, AND THE LEARNING OF LANDMARK STABILITY
PLACE CELLS, HEAD DIRECTION CELLS, AND THE LEARNING OF LANDMARK STABILITY
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DOI：
10.1523/jneurosci.15-03-01648.1995
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发表时间：
1995-03-01
影响因子：
5.3
通讯作者：
MCNAUGHTON, BL
中科院分区：
文献类型：
--
作者：
KNIERIM, JJ;KUDRIMOTI, HS;MCNAUGHTON, BL
先前的研究表明，海马位置场是由环境中的显著感觉线索控制的，因为线索的旋转会导致位置场的相等旋转。我们训练大鼠在一个灰色圆柱体中寻找食物颗粒，圆柱体有一个突出的方向提示，一个覆盖圆柱体壁90度的白色卡片。一半的老鼠在被放入圆筒之前迷失方向，以扰乱它们的内部方向感。另一半老鼠在被放入圆筒之前并没有迷失方向;对于这些老鼠来说，提示卡和它们的内部方向感之间可能存在一致的关系。随后，我们记录了两组大鼠的海马位置细胞和丘脑头部方向细胞，因为它们在圆柱体中移动;在一些会话之间，圆柱体和提示卡旋转到一个新的方向。所有大鼠在记录前均迷失方向。在这些条件下，提示卡对训练中迷失方向的大鼠的位置场和头部方向细胞的控制要比没有迷失方向的大鼠弱得多。对于前一组，位置场经常相对于提示卡旋转或在会话之间完全改变其放电特性。在所有记录会话中，头部方向细胞和位置细胞都是强耦合的。看来，强度的线索控制的位置细胞和头部方向细胞取决于大鼠的学习感知的稳定性的线索。
Previous studies have shown that hippocampal place fields are controlled by the salient sensory cues in the environment, in that rotation of the cues causes an equal rotation of the place fields. We trained rats to forage for food pellets in a gray cylinder with a single salient directional cue, a white card covering 90 degrees of the cylinder wall. Half of the rats were disoriented before being placed in the cylinder, in order to disrupt their internal sense of direction. The other half were not disoriented before being placed in the cylinder; for these rats, there was presumably a consistent relationship between the cue card and their internal direction sense. We subsequently recorded hippocampal place cells and thalamic head direction cells from both groups of rats as they moved in the cylinder; between some sessions the cylinder and cue card were rotated to a new direction. All rats were disoriented before recording. Under these conditions, the cue card had much weaker control over the place fields and head direction cells in the rats that had been disoriented during training than in the rats that had not been disoriented. For the former group, the place fields often rotated relative to the cue card or completely changed their firing properties between sessions, In all recording sessions, the head direction cells and place cells were strongly coupled. It appears that the strength of cue control over place cells and head direction cells depends on the rat's learned perception of the stability of the cues.