Health-related quality of life in patients with inflammatory bowel disease five years after the initial diagnosis
Health-related quality of life in patients with inflammatory bowel disease five years after the initial diagnosis
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DOI：
10.1080/00365520310008386
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发表时间：
2004-04-01
影响因子：
1.9
通讯作者：
Moum, B
中科院分区：
文献类型：
--
作者：
Bernklev, T;Jahnsen, J;Moum, B
背景资料：健康相关生活质量（HRQOL）已成为评价炎症性肠病（IBD）患者满意度的重要工具。到目前为止，很少有前瞻性的随访研究已经完成，以确定影响HRQOL的变量。我们的目的是确定人口统计学和临床变量，影响诊断后5年的溃疡性结肠炎（UC）或克罗恩病（CD）患者的HRQOL纳入1990年至1994年的前瞻性随访研究（IBSEN研究）。研究方法：所有患者都完成了炎症性肠病问卷（IBDQ），这是一种翻译成挪威语并经过验证的疾病特异性生活质量问卷。我们提供了497例患者的数据（328例UC患者和169例CD患者，平均年龄43.3岁，48%为女性）。分析年龄、性别、吸烟、症状严重程度、疾病分布、风湿症状和手术对IBD患者HRQOL的影响。结果：女性IBDQ总分较男性降低10分，CD患者较UC患者降低7.5分。中/重度症状患者的评分比无症状患者低50分。有风湿症状的患者比无风湿症状的患者总分低10分。所有差异均具有统计学显著性。多元回归分析显示，症状严重程度、风湿症状和女性是两个诊断组HRQOL降低的最强预测因素。结论：IBD症状、风湿症状和女性对IBDQ测量的HRQOL有显著影响。回归分析证实了这一点。
Background: Health-related quality of life (HRQOL) has become an important tool in evaluating patient satisfaction in inflammatory bowel disease (IBD). So far, few prospective follow-up studies have been done to identify variables that influence HRQOL. We aimed to identify demographic and clinical variables that influence HRQOL 5 years after diagnosis in patients with ulcerative colitis (UC) or Crohn disease (CD) included in a prospective follow-up study from 1990 to 1994 (the IBSEN study). Methods: All patients completed the Inflammatory Bowel Disease Questionnaire (IBDQ), a disease-specific quality-of-life questionnaire translated into Norwegian and validated. We present data from 497 patients (328 UC patients and 169 CD patients, mean age 43.3 years, 48% female). The impact of age, gender, smoking, symptom severity, disease distribution, rheumatic symptoms and surgery on IBD patients' HRQOL was analysed. Results: Women had a reduction in IBDQ total score of 10 points compared to men, CD patients had a reduction of 7.5 compared to UC patients. The patients with moderate/severe symptoms had a 50 points lower score than the patients without symptoms. The patients with rheumatic symptoms had a 10 points lower total score than the patients without these symptoms. All differences were statistically significant. The multiple regression analysis showed that symptom severity, rheumatic symptoms and female gender were the strongest predictors of reduction in HRQOL for both diagnosis groups. Conclusion: IBD symptoms, rheumatic symptoms and female gender have a significant influence on patients' HRQOL as measured by IBDQ. This was confirmed by the regression analysis.