Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites
Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites
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DOI：
10.1016/j.biomaterials.2007.12.040
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发表时间：
2008-04-01
期刊：
影响因子：
14
通讯作者：
Boccaccini, Aldo R.
中科院分区：
文献类型：
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作者：
Misra, Superb K.;Mohn, Dirk;Boccaccini, Aldo R.
比较了微米级（m-BG）和纳米级（n-BG）生物活性玻璃颗粒的引入对聚3羟基丁酸酯（P（3 HB））/生物活性玻璃复合体系的各种性能（热性能、力学性能和微观结构）的影响。采用溶剂浇铸法制备了3种不同m-BG和n-BG浓度（分别为10、20和30wt%）的P（3 HB）/生物活性玻璃复合膜。与m-BG相比，n-BG颗粒的加入对复合材料的模量具有显著的硬化效果。然而，由于n-BG和m-BG颗粒的添加，复合材料的热性能没有显著差异。系统地添加n-BG颗粒在复合材料的表面上诱导了纳米结构的形貌，这在m-BG复合材料中通过SEM是不可见的。与未填充的聚合物和m-BG复合材料相比，由n-BG颗粒诱导的这种表面效应显著改善了n-BG复合材料上的总蛋白质吸附。在模拟体液（SBF）中的短期体外降解（30天）研究表明P（3 HB）/n-BG复合材料具有高水平的生物活性以及较高的吸水性。此外，使用MG-63细胞的细胞增殖研究表明，两种类型的P（3 HB）/生物活性玻璃复合系统具有良好的生物相容性。本研究的结果证实，添加纳米生物活性玻璃颗粒的复合材料系统的机械和结构性能相比，微粒有更显着的效果，以及增强蛋白质吸附，两个理想的效果的复合材料在组织工程中的应用。(C)2008爱思唯尔有限公司保留所有权利。
This study compares the effects of introducing micro (m-BG) and nanoscale (n-BG) bioactive glass particles on the various properties (thermal, mechanical and microstructural) of poly(3hydroxybutyrate) (P(3HB))/bioactive glass composite systems. P(3HB)/bioactive glass composite films with three different concentrations of m-BG and n-BG (10, 20 and 30 wt%, respectively) were prepared by a solvent casting technique. The addition of n-BG particles had a significant stiffening effect on the composites, modulus when compared with m-BG. However, there were no significant differences in the thermal properties of the composites due to the addition of n-BG and m-BG particles. The systematic addition of n-BG particles induced a nanostructured topography on the surface of the composites, which was not visible by SEM in m-BG composites. This surface effect induced by n-BG particles considerably improved the total protein adsorption on the n-BG composites compared to the unfilled polymer and the m-BG composites. A short term in vitro degradation (30 days) study in simulated body fluid (SBF) showed a high level of bioactivity as well as higher water absorption for the P(3HB)/n-BG composites. Furthermore, a cell proliferation study using MG-63 cells demonstrated the good biocompatibility of both types of P(3HB)/bioactive glass composite systems. The results of this investigation confirm that the addition of nanosized bioactive glass particles had a more significant effect on the mechanical and structural properties of a composite system in comparison with microparticles, as well as enhancing protein adsorption, two desirable effects for the application of the composites in tissue engineering. (C) 2008 Elsevier Ltd. All rights reserved.