A divergent pattern of sensory axonal projections is rendered convergent by second-order neurons in the accessory olfactory bulb
A divergent pattern of sensory axonal projections is rendered convergent by second-order neurons in the accessory olfactory bulb
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DOI：
10.1016/s0896-6273(02)00904-2
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发表时间：
2002-09-12
期刊：
影响因子：
16.2
通讯作者：
Mombaerts, P
中科院分区：
文献类型：
--
作者：
Del Punta, K;Puche, A;Mombaerts, P
哺乳动物的犁鼻系统专门负责信息素的检测。副嗅球的神经回路为信息素信息的编码提供了解剖学基础。在这里，我们描述了犁鼻感觉神经元向AOB的轴突投射模式和二级神经元的树突连接模式。表达V2R类犁鼻受体特定基因的基因追踪感觉神经元将其轴突投射到分布在AOB全球保守区域的6至10个肾小球，这一主题类似于表达V1R的神经元。令人惊讶的是，二级神经元倾向于将树突投射到由表达相同V1R或相同V2R基因的感觉神经元轴突支配的肾小球。嗅球中受体类型信息的汇聚可能代表了嗅觉系统中的一种常见设计。
The mammalian vomeronasal system is specialized in pheromone detection. The neural circuitry of the accessory olfactory bulb (AOB) provides an anatomical substrate for the coding of pheromone information. Here, we describe the axonal projection pattern of vomeronasal sensory neurons to the AOB and the dendritic connectivity pattern of second-order neurons. Genetically traced sensory neurons expressing a given gene of the V2R class of vomeronasal receptors project their axons to six to ten glomeruli distributed in globally conserved areas of the AOB, a theme similar to V1R-expressing neurons. Surprisingly, second-order neurons tend to project their dendrites to glomeruli innervated by axons of sensory neurons expressing the same V1R or the same V2R gene. Convergence of receptor type information in the olfactory bulb may represent a common design in olfactory systems.