Experimental induction and termination of acute psychological stress in human volunteers: Effects on immunological, neuroendocrine, cardiovascular, and psychological parameters
Experimental induction and termination of acute psychological stress in human volunteers: Effects on immunological, neuroendocrine, cardiovascular, and psychological parameters
复制标题
DOI：
10.1006/brbi.1997.0511
复制
发表时间：
1998-03-01
影响因子：
15.1
通讯作者：
Zinder, O
中科院分区：
文献类型：
--
作者：
Breznitz, S;Ben-Zur, H;Zinder, O
本研究探讨应激控制实验操作对生理和心理反应的影响。50名年轻的成年男性志愿者被暴露在不可避免的、痛苦的电击威胁所引起的12分钟的压力下。在压力期之前或之后的12分钟没有这种威胁。在每个时间段的第11分钟和第12分钟抽血。预期威胁导致自然杀伤（NK）淋巴细胞的比例和细胞毒性活性显著升高，血浆肾上腺素水平升高，脉搏率升高。报告的紧张程度。并降低CD4/CD8比值。在同样短的时间内，无威胁期诱导肾上腺素、脉搏率和张力恢复到基线值，NK淋巴细胞的细胞毒性活性低于基线水平。研究结果强调，在短暂的急性心理应激过程中，生理变化可能会迅速发生，而在应激源缓解后，生理变化又会迅速逆转。(C) 1998学术出版社。
The present research investigated the effects of controlled experimental manipulations of stress on biological and psychological reactions. Fifty young adult male volunteers were exposed to a 12-min period of stress induced by the threat of an unavoidable, painful electric shock. A 12-min period without this threat preceded or followed the stress period. Blood was drawn during the il th and the 12th minute of each period. Anticipatory threat led to significant elevations in the proportions and cytotoxic activity of natural killer (NK) lymphocytes, plasma epinephrine levels, pulse rate. and reported level of tension. and to a reduction in the CD4/CD8 ratios. The no-threat period induced a return to baseline values for epinephrine, pulse rate, and tension, and lower than baseline levels for cytotoxic activity of NK lymphocytes, within a similarly short time span. The findings underline the rapidity with which physiological changes may transpire in the course of a brief and acute period of psychological stress, and the rapidity of their reversal upon relief from the stressor. (C) 1998 Academic Press.