Functional heterogeneity within Broca's area during verbal working memory
Functional heterogeneity within Broca's area during verbal working memory
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DOI：
10.1016/s0031-9384(02)00899-5
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发表时间：
2002-12-01
影响因子：
2.9
通讯作者：
Fiez, JA
中科院分区：
文献类型：
--
作者：
Chein, JM;Fissell, K;Fiez, JA
在先前的功能性磁共振成像（fMRI）研究中，我们发现左侧额下回的两个子区域在言语工作记忆任务期间呈现出不同的活动模式。具体而言，一个更靠背部的区域与任务表现相关，而一个更靠腹部的区域对词汇状态敏感。为了检验这一发现的准确性，我们开发了一种用于神经影像结果元分析的新方法。在这种方法中，围绕从已发表的神经影像研究中获得的立体定位坐标形成高斯概率分布。然后将这些概率分布合并，以确定不同研究中的汇聚区域。当将这种方法应用于先前的工作记忆研究时，结果在很大程度上与早期对工作记忆文献的综述相似，但也证实了我们的实证发现，即布洛卡区内部存在不同的焦点。这种元分析技术的进一步应用证实了这些区域在任务表现和亚词汇加工方面的分离。这些结果有助于验证一种用于神经影像发现元分析的新方法，该方法避免了其他方法中涉及的许多主观假设。（C）2002爱思唯尔科学公司。保留所有权利。
in previous fMRI research, we found that two subregions of the left inferior frontal cortex showed distinct patterns of activity during a verbal working memory task. Specifically, a more dorsal region tracked with performance, while a more ventral region was sensitive to lexical status. To test the veracity of this finding, we developed a new method for meta-analysis of neuroimaging results. In this method, Gaussian probability distributions are formed around stereotaxic coordinates obtained from published neuroimaging studies. These probability distributions are then combined to identify regions of convergence across studies. When this method was applied to prior studies of working memory, the results largely paralleled those from earlier reviews of the literature on working memory, but also confirmed our empirical findings showing distinct foci within Broca's area. Further application of this meta-analytic technique substantiated the dissociation in these regions for performance and sublexical processing. These results help to validate a novel approach for meta-analysis of neuroimaging findings that avoids many of the subjective assumptions involved in alternative approaches. (C) 2002 Elsevier Science Inc. All rights reserved.