Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation.
Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation.
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叶酸摄入对妊娠健康结果的影响：系统评价和荟萃分析对出生体重，胎盘体重和妊娠长度的影响。
DOI：
10.1186/1475-2891-11-75
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发表时间：
2012-09-19
影响因子：
5.4
通讯作者：
Decsi T
中科院分区：
文献类型：
--
作者：
Fekete K;Berti C;Trovato M;Lohner S;Dullemeijer C;Souverein OW;Cetin I;Decsi T
在怀孕前和怀孕后不久补充叶酸的有益效果是公认的，而在第二和第三个三个月期间补充叶酸的效果是有争议的，记录很少。我们的目的是系统地回顾随机对照试验（RCT），研究叶酸补充剂对出生体重，胎盘重量和妊娠期的影响，并评估叶酸摄入量（叶酸加膳食叶酸）和健康结果之间的剂量反应关系。检索MEDLINE、EMBASE和科克伦图书馆CENTRAL数据库中从开始到2010年2月的RCT，研究叶酸摄入量和妊娠期健康结局。我们使用loge-loge量表上的随机效应荟萃分析计算了总体摄入-健康回归系数（）。分析了8个随机对照试验的10个研究的数据。叶酸摄入量与新生儿出生体重呈显著的剂量-反应关系（P=0.001），总体为0.03（95%可信区间（CI）：0.01，0.05）。这种关系表明，叶酸摄入量每增加两倍，出生体重就会增加2%。相反，我们没有发现叶酸补充剂对胎盘重量或妊娠时间有任何有益的影响。目前缺乏关于叶酸补充剂对妊娠期健康结局影响的良好随机对照试验。本系统评价中概述的剂量反应方法可能有助于设计叶酸补充剂的临床研究和为孕妇提供建议。
The beneficial effect of folic acid supplementation before and shortly after conception is well recognized, whereas the effect of supplementation during the second and third trimesters is controversial and poorly documented. Our aims were to systematically review randomized controlled trials (RCTs) investigating the effect of folate supplementation on birth weight, placental weight and length of gestation and to assess the dose–response relationship between folate intake (folic acid plus dietary folate) and health outcomes. The MEDLINE, EMBASE and Cochrane Library CENTRAL databases were searched from inception to February 2010 for RCTs in which folate intake and health outcomes in pregnancy were investigated. We calculated the overall intake-health regression coefficient ( ) by using random-effects meta-analysis on a loge-loge scale. Data of 10 studies from 8 RCTs were analyzed. We found significant dose–response relationship between folate intake and birth weight (P=0.001), the overall was 0.03 (95% confidence interval (CI): 0.01, 0.05). This relationship indicated 2% increase in birth weight for every two-fold increase in folate intake. In contrast, we did not find any beneficial effect of folate supplementation on placental weight or on length of gestation. There is a paucity of well-conducted RCTs investigating the effect of folate supplementation on health outcomes in pregnancy. The dose–response methodology outlined in the present systematic review may be useful for designing clinical studies on folate supplementation and for developing recommendations for pregnant women.
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影响因子：
158.5
作者：
CZEIZEL, AE;DUDAS, I
通讯作者：
DUDAS, I
影响因子：
4.2
作者：
Rao, S;Yajnik, CS;Desai, B
通讯作者：
Desai, B
DOI：
10.1590/s1415-52732002000200008
发表时间：
2002-08-01
期刊：
Revista de Nutrição
影响因子：
--
作者：
NOGUEIRA, Nadir do Nascimento;MACÊDO, Antônio da Silva;COZZOLINO, Sílvia Maria Franciscato
通讯作者：
COZZOLINO, Sílvia Maria Franciscato
影响因子：
7.1
作者：
Pitkin, Roy M.
通讯作者：
Pitkin, Roy M.
DOI：
10.1016/0002-9378(75)90179-9
发表时间：
1975-01-01
影响因子：
9.8
作者：
IYENGAR, L;RAJALAKSHMI, K
通讯作者：
RAJALAKSHMI, K