Brain volumetric and fractal analysis of synthetic MRI: A comparative study with conventional 3D T1-weighted images
Brain volumetric and fractal analysis of synthetic MRI: A comparative study with conventional 3D T1-weighted images
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DOI：
10.1016/j.ejrad.2021.109782
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发表时间：
2021-05-25
影响因子：
3.3
通讯作者：
Qian, Long
中科院分区：
文献类型：
--
作者：
Liu, Sidong;Meng, Tiebao;Qian, Long
目的：基于合成MRI（SyMRI）的脑体积测量方法简单、快速，但基于SyMRI和3DT 1 WI的脑体积和形态测量的一致性有待进一步研究。本研究评价了空间分辨率对SyMRI脑体积和形态测量的影响，并检验了SyMRI脑体积和形态测量结果与3DT 1 WI脑体积和形态测量结果的一致性。方法：对30名健康受试者进行脑体积和分形分析，每名受试者接受4次不同空间分辨率（1 x 1 x 2 mm，1 x 1 x 3 mm，1 x 1 x 4 mm，2 x 2 x 2 mm）和3D T1 WI（1 x 1 x 1 mm各向同性）的SyMRI采集。使用单向非参数Kruskal-Wallis检验和事后Dwass-Steel-Critchlow-Fligner检验检验SyMRI测量的一致性。使用线性回归模型评价SyMRI和3D T1 WI衍生测量值之间的相关性。结果如下：我们的研究结果表明，无论是在平面内和通过平面分辨率显示对脑体积测量的影响，而脑实质体积显示在SyMRI采集的高度一致性，并与3D T1 WI的测量结果高度相关。此外，在体积和分形分析中，与其他SyMRI采集相比，1 x 1 x 4 mm分辨率的SyMRI显示出与3D T1 WI的最强关联。SyMRI和3DT 1 WI图像的灰度和白色物质的分形维数存在显著性差异。结论：我们的研究结果表明，SyMRI的测量具有相对较高的平面内和较低的通过平面的分辨率（1 × 1 × 4 mm）更接近3D T1 WI。
Purpose: The estimation of brain volumetric measurements based on Synthetic MRI (SyMRI) is easy and fast, however, the consistency of brain volumetric and morphologic measurements based on SyMRI and 3D T1WI should be further addressed. The current study evaluated the impact of spatial resolution on brain volumetric and morphologic measurements using SyMRI, and test whether the brain measurements derived from SyMRI were consistent with those resulted from 3D T1WI. Method: Brain volumetric and fractal analysis were applied to thirty healthy subjects, each underwent four SyMRI acquisitions with different spatial resolutions (1 x 1 x 2 mm, 1 x 1x3mm, 1 x 1 x 4 mm, 2 x 2 x 2 mm) and a 3D T1WI (1 x 1 x 1 mm isotropic). The consistency of the SyMRI measurements was tested using one-way nonparametric Kruskal-Wallis test and post hoc Dwass-Steel-Critchlow-Fligner test. The association between SyMRI and 3D T1WI derived measurements was evaluated using linear regression models. Results: Our results demonstrated that both in- and through-plane resolutions show an impact on brain volumetric measurements, while brain parenchymal volume showed high consistency across the SyMRI acquisitions, and high association with the measurements from 3D T1WI. In addition, SyMRI with 1 x 1 x 4 mm resolution showed the strongest association with 3D T1WI compared to other SyMRI acquisitions in both volumetric and fractal analyses. Moreover, substantial differences were found in fractal dimension of both gray and white matter between the SyMRI and 3D T1WI tissue segmentations. Conclusions: Our results suggested that the measurements from SyMRI with relatively higher in-plane and lower through-plane resolution (1 x 1 x 4 mm) are much closer to 3D T1WI.