Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders
Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders
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DOI：
10.1038/nm.2845
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发表时间：
2012-07-01
期刊：
影响因子：
82.9
通讯作者：
Courtine, Gregoire
中科院分区：
文献类型：
--
作者：
Dominici, Nadia;Keller, Urs;Courtine, Gregoire
中枢神经系统（CNS）疾病明显损害运动模式的产生和平衡，但技术限制阻碍了对这些子功能的独立评估和康复。在这里，我们介绍了一种多功能机器人界面，用于在大鼠自然行走行为期间独立评估、启用和训练模式生成和平衡。在评估模式下，机器人界面可对脊髓损伤 (SCI) 和中风后的模式生成和动态平衡进行详细评估。在启用模式下，机器人充当推进或姿势神经假体，立即促进意想不到的运动能力，包括完全 SCI 后的地上行走、部分 SCI 后的爬楼梯以及中风后不久的精确爪子放置。在训练模式下，机器人康复、硬膜外电刺激和单胺激动剂可帮助脊髓损伤瘫痪大鼠重建重量支撑运动、协调转向和平衡。这种新的机器人技术和相关概念对于动物和人类中枢神经系统疾病后的运动功能评估和恢复具有广泛的影响。
Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluate, enable and train pattern generation and balance independently during natural walking behaviors in rats. In evaluation mode, the robotic interface affords detailed assessments of pattern generation and dynamic equilibrium after spinal cord injury (SCI) and stroke. In enabling mode, the robot acts as a propulsive or postural neuroprosthesis that instantly promotes unexpected locomotor capacities including overground walking after complete SCI, stair climbing following partial SCI and precise paw placement shortly after stroke. In training mode, robot-enabled rehabilitation, epidural electrical stimulation and monoamine agonists reestablish weight-supported locomotion, coordinated steering and balance in rats with a paralyzing SCI. This new robotic technology and associated concepts have broad implications for both assessing and restoring motor functions after CNS disorders, both in animals and in humans.