Leptin levels predict survival in pulmonary arterial hypertension.
Leptin levels predict survival in pulmonary arterial hypertension.
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DOI：
10.4103/2045-8932.97607
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发表时间：
2012-04-01
影响因子：
2.6
通讯作者：
Dweik, Raed A
中科院分区：
文献类型：
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作者：
Tonelli, Adriano R;Aytekin, Metin;Dweik, Raed A
有证据表明，瘦素参与心血管系统的相关过程。低血清瘦素水平与冠状动脉、糖尿病或慢性肾病患者心血管事件和死亡率增加相关。我们假设瘦素在肺动脉高压（PAH）中增加，并提供预后信息。我们将瘦素水平与临床数据相关联，并评估其与生存率的关系。研究了67例PAH患者和29例健康对照。血浆瘦素水平与BMI呈非线性相关。瘦素水平
Evidence suggests that leptin is involved in relevant processes in the cardiovascular system. Low serum leptin levels have been associated with increased cardiovascular events and mortality in patients with coronary artery, diabetes, or chronic kidney disease. We hypothesized that leptin is increased in pulmonary arterial hypertension (PAH) and provides prognostic information. We correlated leptin levels with clinical data and assessed its association with survival. Sixty-seven patients with PAH and 29 healthy controls were studied. Plasma leptin levels were nonlinearly associated with BMI. Leptin level