MAGNITUDE OF DILATATION OF LARGE AND SMALL CORONARY-ARTERIES BY NITROGLYCERIN
MAGNITUDE OF DILATATION OF LARGE AND SMALL CORONARY-ARTERIES BY NITROGLYCERIN
复制标题
DOI：
10.1161/01.cir.64.2.324
复制
发表时间：
1981-01-01
期刊：
影响因子：
37.8
通讯作者：
CONTI, CR
中科院分区：
文献类型：
--
作者：
FELDMAN, RL;PEPINE, CJ;CONTI, CR
本文测定了34例左冠状动脉心外膜大段、心肌内小段（0.3- 1.0mm）、狭窄段及侧支循环充盈段的舒张反应。在硝酸甘油（0.4 mg，舌下含服）给药前后，使用照相点胶片和校准的6倍观察装置，通过定量放大冠状动脉造影术进行测量。左主CA、近端、中间和远端前降支和回旋段以及小CA显示出不同程度的扩张。当将扩张幅度与血管的控制直径及其位置进行比较时，控制直径是显著的自变量。具有最小对照直径的CA显示最大程度的血管舒张。由侧支填充的CA分支的血管舒张程度与对照直径相当的CA相似。尽管冠状动脉狭窄扩张，但扩张幅度小于在相似对照直径的非狭窄动脉段中观察到的扩张幅度。当排除狭窄区域时，无论患者是否患有CA疾病，结果都相似。硝酸甘油对CA血管舒张反应的主要决定因素显然是硝酸甘油之前动脉的大小。
Vasodilatory responses of segments of large epicardial left coronary artery (CA), small intramyocardial CA (0.3-1.0 mm), coronary stenoses and CA filled by collaterals were determined in 34 patients. Measurements were made before and after nitroglycerin (0.4 mg, sublingual) by means of quantitative magnification coronary angiography using photospot film and a calibrated 6-power viewing device. The left main CA, proximal, middle and distal anterior descending and circumflex segments, and small CA showed dilatation that varied in magnitude. When magnitude of dilatation was compared with control diameter of the vessel and its location, control diameter was the significant independent variable. CA with the smallest control diameter showed the greatest magnitude of vasodilatation. CA branches filled by collaterals had vasodilatation similar in magnitude to that of CA of comparable control diameter. Although coronary stenoses dilated, the magnitude of dilatation was less than that observed in nonstenosed arterial segments of similar control diameter. When areas of stenosis were excluded, results were similar regardless of whether the patient had CA disease. A principal determinant of the CA vasodilatory response to nitroglycerin apparently is the size of the artery before nitroglycerin.