Potential Maternal and Infant Outcomes from Coronavirus 2019-nCoV (SARS-CoV-2) Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections
Potential Maternal and Infant Outcomes from Coronavirus 2019-nCoV (SARS-CoV-2) Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections
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DOI：
10.3390/v12020194
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发表时间：
2020-02-01
期刊：
影响因子：
4.7
通讯作者：
Graham, Ashley L.
中科院分区：
文献类型：
--
作者：
Schwartz, David A.;Graham, Ashley L.
2019年12月初，在中华人民共和国拥有1100万人口的武汉市发现了一批不明原因的肺炎病例。进一步的调查显示，这些病例是由一种新发现的冠状病毒感染引起的，最初被称为2019-nCoV，随后被称为SARS-CoV-2。感染迅速通过中国，传播到泰国和日本，通过感染者乘飞机旅行扩展到邻国，最终到达多个国家和大陆。与其他导致中东呼吸综合征（MERS）和严重急性呼吸综合征（SARS）的冠状病毒类似，据报道，新型冠状病毒通过自然气溶胶在人与人之间传播。在这一流行病的早期阶段，病死率估计约为2%，大多数死亡发生在特殊人群中。不幸的是，在怀孕期间感染冠状病毒的经验有限，现在看来可以肯定的是，孕妇在目前的2019-nCoV流行期间受到感染。为了评估武汉2019-nCoV导致孕产妇、胎儿和新生儿发病率以及其他不良产科结局的可能性，本文回顾了已发表的关于SARS、MERS和其他冠状病毒感染对孕妇及其婴儿的流行病学和临床影响的数据。还建议在设计，临床试验和实施未来的2019-nCoV疫苗时考虑孕妇。
In early December 2019 a cluster of cases of pneumonia of unknown cause was identified in Wuhan, a city of 11 million persons in the People's Republic of China. Further investigation revealed these cases to result from infection with a newly identified coronavirus, initially termed 2019-nCoV and subsequently SARS-CoV-2. The infection moved rapidly through China, spread to Thailand and Japan, extended into adjacent countries through infected persons travelling by air, eventually reaching multiple countries and continents. Similar to such other coronaviruses as those causing the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), the new coronavirus was reported to spread via natural aerosols from human-to-human. In the early stages of this epidemic the case fatality rate is estimated to be approximately 2%, with the majority of deaths occurring in special populations. Unfortunately, there is limited experience with coronavirus infections during pregnancy, and it now appears certain that pregnant women have become infected during the present 2019-nCoV epidemic. In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. Recommendations are also made for the consideration of pregnant women in the design, clinical trials, and implementation of future 2019-nCoV vaccines.